Cited 0 times in Scipus Cited Count

Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients

DC Field Value Language
dc.contributor.authorKim, B-
dc.contributor.authorCho, EJ-
dc.contributor.authorYoon, JH-
dc.contributor.authorKim, SS-
dc.contributor.authorCheong, JY-
dc.contributor.authorCho, SW-
dc.contributor.authorPark, T-
dc.date.accessioned2022-11-29T01:43:38Z-
dc.date.available2022-11-29T01:43:38Z-
dc.date.issued2020-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23037-
dc.description.abstractAberrations of the human microbiome are associated with diverse liver diseases, including hepatocellular carcinoma (HCC). Even if we can associate specific microbes with particular diseases, it is difficult to know mechanistically how the microbe contributes to the pathophysiology. Here, we sought to reveal the functional potential of the HCC-associated microbiome with the human metabolome which is known to play a role in connecting host phenotype to microbiome function. To utilize both microbiome and metabolomic data sets, we propose an innovative, pathway-based analysis, Hierarchical structural Component Model for pathway analysis of Microbiome and Metabolome (HisCoM-MnM), for integrating microbiome and metabolomic data. In particular, we used pathway information to integrate these two omics data sets, thus providing insight into biological interactions between different biological layers, with regard to the host's phenotype. The application of HisCoM-MnM to data sets from 103 and 97 patients with HCC and liver cirrhosis (LC), respectively, showed that this approach could identify HCC-related pathways related to cancer metabolic reprogramming, in addition to the significant metabolome and metagenome that make up those pathways.-
dc.language.isoen-
dc.titlePathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients-
dc.typeArticle-
dc.identifier.pmid32967314-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563418-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordcirrhosis-
dc.subject.keywordmicrobiome-
dc.subject.keywordmetabolome-
dc.subject.keywordmultiomics-
dc.subject.keywordintegration-
dc.subject.keywordmetabolic pathway-
dc.contributor.affiliatedAuthorKim, SS-
dc.contributor.affiliatedAuthorCheong, JY-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/cancers12092705-
dc.citation.titleCancers-
dc.citation.volume12-
dc.citation.number9-
dc.citation.date2020-
dc.citation.startPage2705-
dc.citation.endPage2705-
dc.identifier.bibliographicCitationCancers, 12(9). : 2705-2705, 2020-
dc.identifier.eissn2072-6694-
dc.relation.journalidJ020726694-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Files in This Item:
32967314.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse