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Multiple actinic keratoses with in vitiliginous patches in a patient with non-segmental vitiligo

Other Title
비분절형 백반증 환자의 노출부위 탈색소반에서 발생한 다발성 광선각화증
Shin, J  | Kim, DY | Park, S | Koo, JS | Hann, SK | Oh, SH
Korean journal of dermatology, 58(1). : 39-42, 2020
Journal Title
Korean journal of dermatology
A 74-year-old man visited our department with complaints of multiple asymptomatic erythematous scaly crusted patches on the scalp. He had non-segmental vitiligo with the extent of over 20% of the body surface area for 30 years. Biopsies showed hyperkeratosis, foci of atypical, pleomorphic keratinocytes along the basal cell layer, and marked solar elastosis, consistent with actinic keratosis (AK). Melan-A and Fontana-Masson staining showed absence of melanin and melanocytes. Despite conflicting data on the prevalence of skin cancers in patients with vitiligo, it is known that vitiligo does not increase nor decrease the risk of skin cancer. Recent studies have reported that patients with vitiligo lesions show increased epidermal expression of wild-type p53 protein than healthy controls. However, a few cases of skin cancer have been reported in patients with vitiligo. Here, we report a case of AK developing in vitiligo lesions. Dermatologists should not overlook the possible occurrence of AK or skin cancers in sun-exposed vitiliginous skin. © 2020 Korean Dermatological Association. All rights reserved.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
Ajou Authors
신, 재용
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