Cited 0 times in Scipus Cited Count

Survival benefits from surgery for stage iva head and neck squamous cell carcinoma: A multi-institutional analysis of 1,033 cases

Park, JO | Park, YM | Jeong, WJ | Shin, YS  | Hong, YT | Choi, IJ | Kim, JW | Woo, SH | Kim, YS | Chang, JW | Kim, MS | Jung, KY | Ahn, SH | Kim, CH  | Hong, KH | Chung, PS | Kim, YM | Kim, SH | Baek, SK
Clinical and experimental otorhinolaryngology, 14(2). : 225-234, 2021
Journal Title
Clinical and experimental otorhinolaryngology
Objectives. Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the locoregional advanced stage (stage IVa), but controversy remains regarding whether stage IVa HSNCs should be treated with upfront surgery or definitive chemoradiation therapy (CRT). The purpose of this study was to compare overall survival (OS) and dis-ease-free survival (DFS) in patients with stage IVa HNSC treated primarily by surgery with curative intent with/with-out (neo)adjuvant treatment (surgery group) versus those treated primarily with CRT (CRT group). Methods. We reviewed data of 1,033 patients with stage IVa HNSC treated with curative intent at 17 cancer centers between 2010 and 2016. Results. Among 1,033 patients, 765 (74.1%) received upfront surgery and 268 (25.9%) received CRT. The 5-year OS and DFS rates were 64.4% and 62.0% in the surgery group and 49.5% and 45.4% in the CRT group, respectively. In multivariate analyses, OS and DFS were better in the surgery group than in the CRT group (odds ratio [OR] for death, 0.762; 95% confidence interval [CI], 0.592–0.981; OR for recurrence, 0.628; 95% CI, 0.492–0.802). In sub-group analyses, the OS and DFS of patients with oropharyngeal cancer were better in the surgery group (OR for death, 0.548; 95% CI, 0.341–0.879; OR for recurrence, 0.598; 95% CI, 0.377–0.948). In the surgery group, patients with laryngeal cancer showed better OS (OR for death, 0.432; 95% CI, 0.211–0.882), while those with hypopharyn-geal cancer DFS was improved (OR for recurrence, 0.506; 95% CI, 0.328–0.780). Conclusion. A survival benefit from surgery may be achieved even in patients with stage IVa HNSC, particularly those with oropharyngeal and laryngeal cancer. Surgery led to a reduction in the recurrence rate in patients with hypopharyn-geal cancer.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Ajou Authors
김, 철호  |  신, 유섭
Full Text Link
Files in This Item:


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.