14 255

Cited 44 times in

Multiple cerebral microbleeds in hyperacute ischemic stroke: impact on prevalence and severity of early hemorrhagic transformation after thrombolytic treatment.

Authors
Kim, HS; Lee, DH; Ryu, CW; Lee, JH; Choi, CG; Kim, SJ; Suh, DC
Citation
AJR. American journal of roentgenology, 186(5):1443-1449, 2006
Journal Title
AJR. American journal of roentgenology
ISSN
0361-803X1546-3141
Abstract
OBJECTIVE: The purpose of our study was to assess whether cerebral microbleeds are related to early hemorrhagic transformation after thrombolytic therapy for hyperacute ischemic stroke. MATERIALS AND METHODS: The cases of 279 patients with suspected ischemic stroke who underwent MRI including T2*-weighted images were retrospectively evaluated. The inclusion criteria were as follows: imaging performed within 6 hr after symptom onset, presence of territorial infarct of anterior circulation, no history of intracerebral hemorrhage, thrombolytic treatment, and available follow-up MR images. Microbleeds were classified according to number as follows: absent (grade 1, 0 bleeds), mild (grade 2, 1-2 bleeds), moderate (grade 3, 3-10 bleeds), and severe (grade 4, > 10 bleeds). The prevalence and severity of early hemorrhagic transformation after thrombolysis were assessed on follow-up images. RESULTS: Among 279 patients, 65 patients (37 men, 28 women; mean age, 67 years) met the inclusion criteria. Microbleeds were found in 25 patients. Early hemorrhagic transformation occurred in nine of 40 patients without microbleeds (grade 1) and in eight of 25 patients with microbleeds: two of 12 patients with grade 2, three of eight patients with grade 3, and three of five patients with grade 4 microbleeds. The presence of symptomatic hemorrhage did not correlate with the number of microbleeds. Results of multivariate logistic regression analysis showed that the presence of microbleeds was not associated with hemorrhagic transformation after thrombolytic treatment. CONCLUSION: Small and large numbers of microbleeds are not independent risk factors for early hemorrhagic transformation and symptomatic hemorrhage after thrombolytic therapy for hyperacute ischemic stroke. Additional studies with large groups of subjects are needed to confirm our conclusion.
MeSH terms
Acute DiseaseAgedAged, 80 and overBrain Ischemia/complications*Brain Ischemia/drug therapyCerebral Hemorrhage/etiology*Cerebral Hemorrhage/pathology*FemaleHumansMaleMiddle AgedPrevalenceRetrospective StudiesSeverity of Illness IndexStroke/complications*Stroke/drug therapyThrombolytic Therapy/adverse effects*
DOI
10.2214/AJR.04.1933
PMID
16632743
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
AJOU Authors
김호성
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse