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Hyperintense nodules on non-enhanced T1-weighted gradient-echo magnetic resonance imaging of cirrhotic liver: fate and clinical implications.

Yu, JS; Lee, JH; Park, MS; Kim, KW
Journal of magnetic resonance imaging : JMRI, 24(3):630-636, 2006
Journal Title
Journal of magnetic resonance imaging : JMRI
PURPOSE: To investigate the fate of hyperintense hepatic nodules on nonenhanced T1-weighted (T1w) gradient-echo (GRE) magnetic resonance (MR) images in cirrhotic patients.

MATERIALS AND METHODS: A total of 79 cirrhotic patients with hyperintense nodules (>5 mm) on precontrast opposed-phase (repetition time (TR)/echo time (TE) = 140/2.7 msec) GRE images from initial MRI without T2-weighted (T2w) hyperintensity or arterial hypervascularity were subjected to analysis of subsequent MR images obtained at intervals of 12-56 months (mean = 24.5 months). Multiplicity of hyperintense nodules (group A, up to 8; group B, >8) was correlated with follow-up changes.

RESULTS: Group B patients were younger (P = 0.003) than group A patients (mean = 47.5 and 56.2 years, respectively). In 66 group A patients, 39 out of 143 lesions (27%) were enlarged, including 20 malignantly transformed or borderline lesions. Of the 104 lesions (the eight largest lesions in each patient) in 13 group B patients, only three (2.9%) were enlarged. The results of best- and worst-case analyses showed that overall the lesions were benign in 91% and 82% of patients, respectively.

CONCLUSION: T1w hyperintense nodules without T2w hyperintensity or arterial hypervascularity in the cirrhotic liver are benign in most cases. In younger patients with numerous macronodules, almost all of these lesions follow a benign course.
MeSH terms
AdultAgedCell Transformation, NeoplasticContrast Media/pharmacologyFemaleFibrosis/diagnosis*Fibrosis/pathology*HumansLiver/pathology*Liver Neoplasms/pathologyMagnetic Resonance Imaging/methods*MaleMiddle AgedRetrospective StudiesTime FactorsTreatment Outcome
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Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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