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Anti-obesity effects of combined cornus officinalis and ribes fasciculatum extract in high-fat diet-induced obese male mice

Authors
Park, E  | Lee, CG  | Jeon, H | Jeong, H | Yeo, S | Yong, Y | Jeong, SY
Citation
Animals : an open access journal from MDPI, 11(11). : 3187-3187, 2021
Journal Title
Animals : an open access journal from MDPI
ISSN
2076-2615
Abstract
Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.
Keywords

DOI
10.3390/ani11113187
PMID
34827919
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
Ajou Authors
박, 은국  |  이, 창근  |  정, 선용
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