Cited 0 times in Scipus Cited Count

3d-printed poly(ε-caprolactone)/hydroxyapatite scaffolds modified with alkaline hydrolysis enhance osteogenesis in vitro

DC Field Value Language
dc.contributor.authorPark, S-
dc.contributor.authorKim, JE-
dc.contributor.authorHan, J-
dc.contributor.authorJeong, S-
dc.contributor.authorLim, JW-
dc.contributor.authorLee, MC-
dc.contributor.authorSon, H-
dc.contributor.authorKim, HB-
dc.contributor.authorChoung, YH-
dc.contributor.authorSeonwoo, H-
dc.contributor.authorChung, JH-
dc.contributor.authorJang, KJ-
dc.date.accessioned2022-12-26T00:39:16Z-
dc.date.available2022-12-26T00:39:16Z-
dc.date.issued2021-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23520-
dc.description.abstractThe 3D-printed bioactive ceramic incorporated Poly(ε-caprolactone) (PCL) scaffolds show great promise as synthetic bone graft substitutes. However, 3D-printed scaffolds still lack adequate surface properties for cells to be attached to them. In this study, we modified the surface characteristics of 3D-printed poly(ε-caprolactone)/hydroxyapatite scaffolds using O2 plasma and sodium hydroxide. The surface property of the alkaline hydrolyzed and O2 plasma-treated PCL/HA scaffolds were evaluated using field-emission scanning microscopy (FE-SEM), Alizarin Red S (ARS) staining, and water contact angle analysis, respectively. The in vitro behavior of the scaffolds was investigated using human dental pulp-derived stem cells (hDPSCs). Cell proliferation of hDPSCs on the scaffolds was evaluated via immunocytochemistry (ICC) and water-soluble tetrazolium salt (WST-1) assay. Osteogenic differentiation of hDPSCs on the scaffolds was further investigated using ARS staining and Western blot analysis. The result of this study shows that alkaline treatment is beneficial for exposing hydroxyapatite particles embedded in the scaffolds compared to O2 plasma treatment, which promotes cell proliferation and differentiation of hDPSCs.-
dc.language.isoen-
dc.title3d-printed poly(ε-caprolactone)/hydroxyapatite scaffolds modified with alkaline hydrolysis enhance osteogenesis in vitro-
dc.typeArticle-
dc.identifier.pmid33466736-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830212/-
dc.subject.keyword3D printing-
dc.subject.keyword3D scaffold-
dc.subject.keywordAlkaline hydrolysis-
dc.subject.keywordHydroxyapatite-
dc.subject.keywordOxygen plasma-
dc.subject.keywordSurface modification-
dc.contributor.affiliatedAuthorChoung, YH-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/polym13020257-
dc.citation.titlePolymers-
dc.citation.volume13-
dc.citation.number2-
dc.citation.date2021-
dc.citation.startPage257-
dc.citation.endPage257-
dc.identifier.bibliographicCitationPolymers, 13(2). : 257-257, 2021-
dc.identifier.eissn2073-4360-
dc.relation.journalidJ020734360-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Files in This Item:
33466736.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse