Cited 0 times in Scipus Cited Count

Modeling subcortical ischemic white matter injury in rodents: Unmet need for a breakthrough in translational research

DC Field Value Language
dc.contributor.authorCui, Y-
dc.contributor.authorJin, X-
dc.contributor.authorChoi, JY-
dc.contributor.authorKim, BG-
dc.date.accessioned2022-12-26T00:39:19Z-
dc.date.available2022-12-26T00:39:19Z-
dc.date.issued2021-
dc.identifier.issn1673-5374-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23545-
dc.description.abstractSubcortical ischemic white matter injury (SIWMI), pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging, is a common cause of cognitive decline in elderly. Despite its high prevalence, it remains unknown how various components of the white matter degenerate in response to chronic ischemia.This incomplete knowledge is in part due to a lack of adequate animal model. The current review introduces various SIWMI animal models and aims to scrutinize their advantages and disadvantages primarily in regard to the pathological manifestations of white matter components. The SIWMI animal models are categorized into 1) chemically induced SIWMI models, 2) vascular occlusive SIWMI models, and 3) SIWMI models with comorbid vascular risk factors. Chemically induced models display consistent lesions in predetermined areas of the white matter, but the abrupt evolution of lesions does not appropriately reflect the progressive pathological processes in human white matter hyperintensities. Vascular occlusive SIWMI models often do not exhibit white matter lesions that are sufficiently unequivocal to be quantified. When combined with comorbid vascular risk factors (specifically hypertension), however, they can produce progressive and definitive white matter lesions including diffuse rarefaction, demyelination, loss of oligodendrocytes, and glial activation, which are by far the closest to those found in human white matter hyperintensities lesions. However, considerable surgical mortality and unpredictable natural deaths during a follow-up period would necessitate further refinements in these models. In the meantime, in vitro SIWMI models that recapitulate myelinated white matter track may be utilized to study molecular mechanisms of the ischemic white matter injury. Appropriate in vivo and in vitro SIWMI models will contribute in a complementary manner to making a breakthrough in developing effective treatment to prevent progression of white matter hyperintensities.-
dc.language.isoen-
dc.titleModeling subcortical ischemic white matter injury in rodents: Unmet need for a breakthrough in translational research-
dc.typeArticle-
dc.identifier.pmid33063714-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067929/-
dc.subject.keywordanimal model-
dc.subject.keywordaxonal degeneration-
dc.subject.keyworddemyelination-
dc.subject.keywordhypertension-
dc.subject.keywordischemia-
dc.subject.keywordoligodendrocytes-
dc.subject.keywordsubcortical ischemic white matter injury-
dc.subject.keywordvascular cognitive impairment-
dc.subject.keywordwhite matter hyperintensities-
dc.contributor.affiliatedAuthorChoi, JY-
dc.contributor.affiliatedAuthorKim, BG-
dc.type.localJournal Papers-
dc.identifier.doi10.4103/1673-5374.295313-
dc.citation.titleNeural regeneration research-
dc.citation.volume16-
dc.citation.number4-
dc.citation.date2021-
dc.citation.startPage638-
dc.citation.endPage642-
dc.identifier.bibliographicCitationNeural regeneration research, 16(4). : 638-642, 2021-
dc.identifier.eissn1876-7958-
dc.relation.journalidJ016735374-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
Files in This Item:
33063714.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse