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Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

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dc.contributor.authorKo, JH-
dc.contributor.authorWoo, HT-
dc.contributor.authorOh, HS-
dc.contributor.authorMoon, SM-
dc.contributor.authorChoi, JY-
dc.contributor.authorLim, JU-
dc.contributor.authorKim, D-
dc.contributor.authorByun, J-
dc.contributor.authorKwon, SH-
dc.contributor.authorKang, D-
dc.contributor.authorHeo, JY-
dc.contributor.authorPeck, KR-
dc.date.accessioned2023-01-05T03:03:06Z-
dc.date.available2023-01-05T03:03:06Z-
dc.date.issued2021-
dc.identifier.issn1226-3303-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23611-
dc.description.abstractBackground/Aims: Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter. Methods: To evaluate the epidemiologic characteristics of HAdV-ARI in the Korean military, we analyzed respiratory virus polymerase chain reaction (RV-PCR) results, pneumonia surveillance results, and severe HAdV cases from all 14 Korean military hospitals from January 2013 to May 2018 and compared these data with nationwide RV surveillance data for the civilian population. Results: A total of 14,630 RV-PCRs was performed at military hospitals. HAdV (45.4%) was the most frequently detected RV, followed by human rhinovirus (12.3%) and influenza virus (6.3%). The percentage of the military positive for HAdV was significantly greater than the percentage of civilians positive for HAdV through-out the study period, with a large outbreak occurring during the winter to spring of 2014 to 2015. The outbreak continued until the end of the study, and non-sea-sonal detections increased over time. The reported number of pneumonia patients also increased during the outbreak. Case fatality rate was 0.075% overall but 15.6% in patients with respiratory failure. The proportion of severe patients did not change significantly during the study period. Conclusions: A large HAdV outbreak is currently ongoing in the Korean mili-tary, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.-
dc.language.isoen-
dc.subject.MESHAdenovirus Infections, Human-
dc.subject.MESHAdenoviruses, Human-
dc.subject.MESHDisease Outbreaks-
dc.subject.MESHHumans-
dc.subject.MESHMilitary Personnel-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRespiratory Tract Infections-
dc.titleOngoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018-
dc.typeArticle-
dc.identifier.pmid31480827-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820655/-
dc.subject.keywordAdenoviridae-
dc.subject.keywordDisease outbreaks-
dc.subject.keywordKorea-
dc.subject.keywordMilitary personnel-
dc.subject.keywordType 55-
dc.contributor.affiliatedAuthorHeo, JY-
dc.type.localJournal Papers-
dc.identifier.doi10.3904/kjim.2019.092-
dc.citation.titleThe Korean journal of internal medicine-
dc.citation.volume36-
dc.citation.number1-
dc.citation.date2021-
dc.citation.startPage205-
dc.citation.endPage213-
dc.identifier.bibliographicCitationThe Korean journal of internal medicine, 36(1). : 205-213, 2021-
dc.identifier.eissn2005-6648-
dc.relation.journalidJ012263303-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
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