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Is ketamine sedation without local anesthesia sufficient for pediatric laceration repair? A double-blind randomized clinical trial

Kwon, H | Lee, JH | Choi, YJ  | Jung, JY
The American journal of emergency medicine, 44. : 208-212, 2021
Journal Title
The American journal of emergency medicine
Purpose: The objective of this study was to evaluate whether sedation with ketamine without local anesthesia was sufficient in children undergoing primary repair. Methods: Randomized, double-blind trial conducted between December 2013 and October 2016 in a tertiary care pediatric emergency department in Korea. Children aged 1 to 10 years requiring sedation for primary repair were randomly assigned to receive local lidocaine anesthesia with ketamine sedation or local saline injection with ketamine sedation. Children's Hospital of Eastern Ontario Pain Scale scores was recorded during the procedures. The pain scales were recorded by nurses who were blinded to the study drugs, before ketamine sedation, after sedation, during the first injection of the study drugs for wound repair, during the first stitch, and after the procedure. Results: Twenty-five were randomized to receive ketamine sedation with local anesthesia and twenty-two to receive ketamine sedation without local anesthesia. There was no significant difference in pain scale before ketamine sedation (difference (mean): −1.11, CI: −2.78-0.55, P value: 0.18), after sedation (difference (mean): −0.60, CI: −2.20-1.01, P = 0.46), during the first injection of the study drugs for wound repair (difference (mean): −0.03, CI: −0.31-0.25, P = 0.84), during the first stitch (difference (mean): −0.15, CI: 6.19–6.79, P = 0.62), during the primary repair (difference (mean): 0.20, CI: −55-0.95, P = 0.59), and after the procedure (difference (mean): 0.17, CI: −0.48-0.82, P = 0.59). Conclusion: Sedating with ketamine for primary wound repair, there was no difference in pain and sedation scales between the patients treated with or without lidocaine local anesthesia, and local anesthesia was not needed.

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Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
Ajou Authors
최, 유진
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