112 283

Cited 13 times in

Vancomycin-tolerant Streptococcus pneumoniae in Korea.

Authors
Sung, H; Shin, HB; Kim, MN; Lee, K; Kim, EC; Song, W; Jeong, SH; Lee, WG; Park, YJ; Eliopoulos, GM
Citation
Journal of clinical microbiology, 44(10):3524-3528, 2006
Journal Title
Journal of clinical microbiology
ISSN
0095-11371098-660X
Abstract
A nationwide surveillance study was undertaken to monitor antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in Korea, with a special focus on vancomycin tolerance. For the 6-month period from March to August 2002, clinical isolates of S. pneumoniae were collected from 11 university hospitals and 1 reference laboratory. One-hundred eighty-eight isolates were measured for lysis rates after exposure to vancomycin for 4 h. Two vancomycin-tolerant S. pneumoniae (VTSP) strains, S3 and H8, were isolated from sputum cultures of two patients, who had stayed in intensive-care units of different hospitals with long-term antibiotic therapy and were not treated for pneumococcal pneumonia. The penicillin, cefotaxime, and vancomycin MICs for S3 were 8 microg/ml, >16 microg/ml, and 0.5 microg/ml, and those for H8 were 2 microg/ml, 2 microg/ml, and 0.5 microg/ml, respectively. While S3 belonged to serotype 23F and was autolysin defective, H8 belonged to serotype 13F and had intact autolysin. These strains were not clonally related as determined by pulsed-field gel electrophoresis of chromosomal DNA. In agreement with previous reports, both isolates showed pairing of TIGR4 vex2 with R6 pep27 and had two identical amino acid substitutions, Q441K in vncS and N25D in vex2. These findings indicate that two VTSP strains have emerged independently in Korea, suggesting a prevalence rate of 1.1%. The emergence of VTSP would be a serious threat in Korea, where there are significant rates of penicillin resistance in S. pneumoniae. Monitoring of the prevalence of VTSP and further investigation of the clinical relevance of VTSP are warranted.
MeSH terms
Amino Acid SequenceAnti-Bacterial Agents/pharmacologyBacterial Proteins/chemistryBacterial Proteins/geneticsHumansKorea/epidemiologyPneumococcal Infections/epidemiology*Pneumococcal Infections/microbiology*Population SurveillanceStreptococcus pneumoniae/drug effects*Streptococcus pneumoniae/isolation & purification*Streptococcus pneumoniae/metabolismVancomycin Resistance*
DOI
10.1128/JCM.00558-06
PMID
17021077
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
AJOU Authors
이위교
Full Text Link
Files in This Item:
3524-3528.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse