Cited 0 times in Scipus Cited Count

Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: A multinational network cohort study

DC Field Value Language
dc.contributor.authorLane, JCE-
dc.contributor.authorWeaver, J-
dc.contributor.authorKostka, K-
dc.contributor.authorDuarte-Salles, T-
dc.contributor.authorAbrahao, MTF-
dc.contributor.authorAlghoul, H-
dc.contributor.authorAlser, O-
dc.contributor.authorAlshammari, TM-
dc.contributor.authorAreia, C-
dc.contributor.authorBiedermann, P-
dc.contributor.authorBanda, JM-
dc.contributor.authorBurn, E-
dc.contributor.authorCasajust, P-
dc.contributor.authorFister, K-
dc.contributor.authorHardin, J-
dc.contributor.authorHester, L-
dc.contributor.authorHripcsak, G-
dc.contributor.authorKaas-Hansen, BS-
dc.contributor.authorKhosla, S-
dc.contributor.authorKolovos, S-
dc.contributor.authorLynch, KE-
dc.contributor.authorMakadia, R-
dc.contributor.authorMehta, PP-
dc.contributor.authorMorales, DR-
dc.contributor.authorMorgan-Stewart, H-
dc.contributor.authorMosseveld, M-
dc.contributor.authorNewby, D-
dc.contributor.authorNyberg, F-
dc.contributor.authorOstropolets, A-
dc.contributor.authorPark, RW-
dc.contributor.authorPrats-Uribe, A-
dc.contributor.authorRao, GA-
dc.contributor.authorReich, C-
dc.contributor.authorRijnbeek, P-
dc.contributor.authorSena, AG-
dc.contributor.authorShoaibi, A-
dc.contributor.authorSpotnitz, M-
dc.contributor.authorSubbian, V-
dc.contributor.authorSuchard, MA-
dc.contributor.authorVizcaya, D-
dc.contributor.authorWen, H-
dc.contributor.authorWilde, MD-
dc.contributor.authorXie, J-
dc.contributor.authorYou, SC-
dc.contributor.authorZhang, L-
dc.contributor.authorLovestone, S-
dc.contributor.authorRyan, P-
dc.contributor.authorPrieto-Alhambra, D-
dc.date.accessioned2023-01-05T03:03:18Z-
dc.date.available2023-01-05T03:03:18Z-
dc.date.issued2021-
dc.identifier.issn1462-0324-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23657-
dc.description.abstractObjectives: Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA. Methods: We performed a new-user cohort study using claims and electronic medical records from 10 sources and 3 countries (Germany, UK and USA). RA patients ≥18 years of age and initiating HCQ were compared with those initiating SSZ (active comparator) and followed up in the short (30 days) and long term (on treatment). Study outcomes included depression, suicide/suicidal ideation and hospitalization for psychosis. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate database-specific calibrated hazard ratios (HRs), with estimates pooled where I2 <40%. Results: A total of 918 144 and 290 383 users of HCQ and SSZ, respectively, were included. No consistent risk of psychiatric events was observed with short-term HCQ (compared with SSZ) use, with meta-analytic HRs of 0.96 (95% CI 0.79, 1.16) for depression, 0.94 (95% CI 0.49, 1.77) for suicide/suicidal ideation and 1.03 (95% CI 0.66, 1.60) for psychosis. No consistent long-term risk was seen, with meta-analytic HRs of 0.94 (95% CI 0.71, 1.26) for depression, 0.77 (95% CI 0.56, 1.07) for suicide/suicidal ideation and 0.99 (95% CI 0.72, 1.35) for psychosis. Conclusion: HCQ as used to treat RA does not appear to increase the risk of depression, suicide/suicidal ideation or psychosis compared with SSZ. No effects were seen in the short or long term. Use at a higher dose or for different indications needs further investigation. Trial registration: Registered with EU PAS (reference no. EUPAS34497; http://www.encepp.eu/encepp/viewResource.htm? id=34498). The full study protocol and analysis source code can be found at https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntirheumatic Agents-
dc.subject.MESHArthritis, Rheumatoid-
dc.subject.MESHCohort Studies-
dc.subject.MESHCOVID-19-
dc.subject.MESHDepression-
dc.subject.MESHFemale-
dc.subject.MESHGermany-
dc.subject.MESHHumans-
dc.subject.MESHHydroxychloroquine-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPsychoses, Substance-Induced-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSuicidal Ideation-
dc.subject.MESHSuicide-
dc.subject.MESHUnited Kingdom-
dc.subject.MESHUnited States-
dc.subject.MESHYoung Adult-
dc.titleRisk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: A multinational network cohort study-
dc.typeArticle-
dc.identifier.pmid33367863-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798671/-
dc.subject.keyworddepression-
dc.subject.keywordepidemiology, RA-
dc.subject.keywordHCQ-
dc.subject.keywordpsychosis-
dc.subject.keywordsafety-
dc.contributor.affiliatedAuthorPark, RW-
dc.type.localJournal Papers-
dc.identifier.doi10.1093/rheumatology/keaa771-
dc.citation.titleRheumatology (Oxford, England)-
dc.citation.volume60-
dc.citation.number7-
dc.citation.date2021-
dc.citation.startPage3222-
dc.citation.endPage3234-
dc.identifier.bibliographicCitationRheumatology (Oxford, England), 60(7). : 3222-3234, 2021-
dc.identifier.eissn1462-0332-
dc.relation.journalidJ014620324-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Files in This Item:
33367863.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse