Cited 0 times in Scipus Cited Count

Adaptive natural killer cells facilitate effector functions of daratumumab in multiple myeloma

DC Field Value Language
dc.contributor.authorCho, H-
dc.contributor.authorKim, KH-
dc.contributor.authorLee, H-
dc.contributor.authorKim, CG-
dc.contributor.authorChung, H-
dc.contributor.authorChoi, YS-
dc.contributor.authorPark, SH-
dc.contributor.authorCheong, JW-
dc.contributor.authorMin, YH-
dc.contributor.authorShin, EC-
dc.contributor.authorKim, JS-
dc.date.accessioned2023-01-05T03:03:29Z-
dc.date.available2023-01-05T03:03:29Z-
dc.date.issued2021-
dc.identifier.issn1078-0432-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23706-
dc.description.abstractPurpose: To investigate the different roles of heterogeneous natural killer (NK)-cell subpopulations in multiple myeloma and to identify NK-cell subsets that support the robust anti-myeloma activity of daratumumab via antibody-dependent cellular cytotoxicity (ADCC). Experimental Design: We performed single-cell RNA sequencing of NK cells from patients with newly diagnosed multiple myeloma (NDMM) and delineated adaptive NK cells in their bone marrow (BM). We further characterized the distinct immunophenotypic features and functions of adaptive NK cells by multicolor flow cytometry in 157 patients with NDMM. Results: Adaptive NK cells exhibit a significantly lower level of CD38 expression compared with conventional NK cells, suggesting that they may evade daratumumab-induced fratricide. Moreover, adaptive NK cells exert robust daratumumab-mediated effector functions ex vivo, including cytokine production and degranulation, compared with conventional NK cells. The composition of adaptive NK cells in BM determines the daratumumab-mediated ex vivo functional activity of BM NK cells in patients with NDMM. Unlike conventional NK cells, sorted adaptive NK cells from the BM of patients with NDMM exert substantial cytotoxic activity against myeloma cells in the presence of daratumumab. Conclusions: Our findings indicate that adaptive NK cells are an important mediator of ADCC in multiple myeloma and support direct future efforts to better predict and improve the treatment outcome of daratumumab by selectively employing adaptive NK cells.-
dc.language.isoen-
dc.subject.MESHAdaptive Immunity-
dc.subject.MESHAntibodies, Monoclonal-
dc.subject.MESHAntibody-Dependent Cell Cytotoxicity-
dc.subject.MESHAntineoplastic Agents, Immunological-
dc.subject.MESHComputational Biology-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHigh-Throughput Nucleotide Sequencing-
dc.subject.MESHHumans-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHKiller Cells, Natural-
dc.subject.MESHLymphocyte Subsets-
dc.subject.MESHMultiple Myeloma-
dc.subject.MESHSingle-Cell Analysis-
dc.titleAdaptive natural killer cells facilitate effector functions of daratumumab in multiple myeloma-
dc.typeArticle-
dc.identifier.pmid33602683-
dc.contributor.affiliatedAuthorChoi, YS-
dc.type.localJournal Papers-
dc.identifier.doi10.1158/1078-0432.CCR-20-3418-
dc.citation.titleClinical cancer research-
dc.citation.volume27-
dc.citation.number10-
dc.citation.date2021-
dc.citation.startPage2947-
dc.citation.endPage2958-
dc.identifier.bibliographicCitationClinical cancer research, 27(10). : 2947-2958, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.relation.journalidJ010780432-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse