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Cancer-Targeted Azo Dye for Two-Photon Photodynamic Therapy in Human Colon Tissue

Lee, DJ | Juvekar, V | Lee, HW | Kim, ES | Noh, CK  | Shin, SJ  | Kim, HM
Analytical chemistry, 93(50). : 16821-16827, 2021
Journal Title
Analytical chemistry
Inappropriate cancer management can be prevented by simultaneous cancer diagnosis, treatment, and real-time assessment of therapeutic processes. Here, we describe the design of a two-photon (TP) photosensitizer (PS), ACC-B, for high temporal and spatioselective near-infrared cancer therapy. ACC-B consisting of a biotin unit significantly enhanced the cancer sensitivity of the PS. Upon TP irradiation, ACC-B generated reactive oxygen species (ROS) through the type I photodynamic therapy (PDT) process and triggered highly selective cancer ablation. In addition, fluorescence microscopy images revealed that ACC-B-loaded live human colon tissues showed a marked difference in ACC-B uptake between normal and cancer tissues, and this property was used for real-time imaging. Upon 770 nm TP treatment, ACC-B generated ROS efficiently in live colon cancer tissues with high spatial selectivity. During PDT, ACC-B can provide in situ spatioselective visualization of cellular behavior and molecular information for therapeutic assessment in specific regions.
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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Ajou Authors
노, 충균  |  신, 성재
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