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Bone mineral density, bone microstructure, and bone turnover markers in females with temporomandibular joint osteoarthritis

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dc.contributor.authorHong, SW-
dc.contributor.authorKang, JH-
dc.date.accessioned2023-01-10T00:38:57Z-
dc.date.available2023-01-10T00:38:57Z-
dc.date.issued2021-
dc.identifier.issn1432-6981-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23849-
dc.description.abstractObjective: The pathogenesis of the temporomandibular joint osteoarthritis (TMJ OA) has not been clearly revealed. This study aimed to investigate the pathogenesis of TMJ OA based on bone metabolism. Methods: Fifty-nine young (mean age 23.4 ± 3.4 years) and 41 post-menopausal females (mean age 57.2 ± 4.6 years) were enrolled. Areal bone mineral density (aBMD) was measured via dual-energy X-ray absorptiometry of the lumbar spine, femoral neck, total hip, and ultradistal radius. Levels of four bone resorption markers, serum ionized calcium and C-telopeptide of type I collagen (CTx) and urinary N-telopeptide of type I collagen and deoxypyridinoline, two bone formation markers, serum bone alkaline phosphatase and osteocalcin, and serum 25-dihydroxyvitamin D were analyzed at baseline and after 12 months. Condylar bone quality was assessed by 3D reconstructed CT images. Results: Significant differences in condylar bone quality and aBMDs of the lumbar spine in accordance with TMJ OA stages were observed in young and post-menopausal females. The level of CTx was significantly associated with the development and progression of TMJ OA only in young females, whereas 25-dihydroxyvitamine D demonstrated significant associations in young and post-menopausal females. Progression of TMJ OA was accompanied by reduced condylar bone quality and concomitant with lower lumbar spine aBMDs in young and post-menopausal females. Conclusion: Bone metabolism and condylar quality might be involved in the development and progression of TMJ OA. Clinical relevance: CTx could be considered as a potential diagnostic and monitoring marker in young females, and vitamin D showed a therapeutic potential for TMJ OA.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers-
dc.subject.MESHBone and Bones-
dc.subject.MESHBone Density-
dc.subject.MESHBone Remodeling-
dc.subject.MESHCollagen Type I-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteoarthritis-
dc.subject.MESHTemporomandibular Joint-
dc.subject.MESHYoung Adult-
dc.titleBone mineral density, bone microstructure, and bone turnover markers in females with temporomandibular joint osteoarthritis-
dc.typeArticle-
dc.identifier.pmid33864149-
dc.subject.keywordBone metabolism-
dc.subject.keywordBone mineral density-
dc.subject.keywordBone turnover marker-
dc.subject.keywordOsteoarthritis-
dc.subject.keywordTemporomandibular joint-
dc.contributor.affiliatedAuthorKang, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00784-021-03946-0-
dc.citation.titleClinical oral investigations-
dc.citation.volume25-
dc.citation.number11-
dc.citation.date2021-
dc.citation.startPage6435-
dc.citation.endPage6448-
dc.identifier.bibliographicCitationClinical oral investigations, 25(11). : 6435-6448, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1436-3771-
dc.relation.journalidJ014326981-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
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