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A computer vision-based automated Figure-8 maze for working memory test in rodents.

Authors
Pedigo, SF; Song, EY; Jung, MW; Kim, JJ
Citation
Journal of neuroscience methods, 156(1-2):10-16, 2006
Journal Title
Journal of neuroscience methods
ISSN
0165-02701872-678X
Abstract
The benchmark test for prefrontal cortex (PFC)-mediated working memory in rodents is a delayed alternation task utilizing variations of T-maze or Figure-8 maze, which requires the animals to make specific arm entry responses for reward. In this task, however, manual procedures involved in shaping target behavior, imposing delays between trials and delivering rewards can potentially influence the animal's performance on the maze. Here, we report an automated Figure-8 maze which does not necessitate experimenter-subject interaction during shaping, training or testing. This system incorporates a computer vision system for tracking, motorized gates to impose delays, and automated reward delivery. The maze is controlled by custom software that records the animal's location and activates the gates according to the animal's behavior and a control algorithm. The program performs calculations of task accuracy, tracks movement sequence through the maze, and provides other dependent variables (such as running speed, time spent in different maze locations, activity level during delay). Testing in rats indicates that the performance accuracy is inversely proportional to the delay interval, decreases with PFC lesions, and that animals anticipate timing during long delays. Thus, our automated Figure-8 maze is effective at assessing working memory and provides novel behavioral measures in rodents.
MeSH terms
AlgorithmsAnimalsComputersMaleMaze Learning/physiology*Memory, Short-Term/physiology*Prefrontal Cortex/physiologyRatsRats, Sprague-DawleyRunningSoftware
DOI
10.1016/j.jneumeth.2006.01.029
PMID
16530272
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
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