Cited 0 times in Scipus Cited Count

Short-Term outcomes of a multicentre randomized clinical trial comparing laparoscopic pylorus-preserving gastrectomy with laparoscopic distal gastrectomy for gastric cancer (the KLASS-04 trial)

DC Field Value Language
dc.contributor.authorPark, DJ-
dc.contributor.authorKim, YW-
dc.contributor.authorYang, HK-
dc.contributor.authorRyu, KW-
dc.contributor.authorHan, SU-
dc.contributor.authorKim, HH-
dc.contributor.authorHyung, WJ-
dc.contributor.authorPark, JH-
dc.contributor.authorSuh, YS-
dc.contributor.authorKwon, OK-
dc.contributor.authorYoon, HM-
dc.contributor.authorKim, W-
dc.contributor.authorPark, YK-
dc.contributor.authorKong, SH-
dc.contributor.authorAhn, SH-
dc.contributor.authorLee, HJ-
dc.date.accessioned2023-01-10T00:39:15Z-
dc.date.available2023-01-10T00:39:15Z-
dc.date.issued2021-
dc.identifier.issn0007-1323-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23919-
dc.description.abstractBackground: There remain concerns about the safety and functional benefit of laparoscopic pylorus-preserving gastrectomy (LPPG) compared with laparoscopic distal gastrectomy (LDG). This study evaluated short-Term outcomes of a randomized clinical trial (RCT) comparing LPPG with LDG for gastric cancer. Methods: The Korean Laparoendoscopic Gastrointestinal Surgery Study (KLASS)-04 trial was an investigator-initiated, open-label, parallel-Assigned, superiority, multicentre RCT in Korea. Patients with cT1N0M0 cancer located in the middle third of the stomach at least 5 cm from the pylorus were randomized to undergo LPPG or LDG. Participants, care givers and those assessing the outcomes were not blinded to group assignment. Outcomes were 30-day postoperative morbidity rate and death at 90 days. Results: Some 256 patients from nine institutions were randomized (LPPG 129 patients, LDG 127 patients) between July 2015 and July 2017 and outcomes for 253 patients were analysed. Postoperative complications within 30 days were seen in 19.3 and 15.5 per cent in the LPPG and LDG groups respectively (P = 0·419). Postoperative pyloric stenosis was observed in nine (7.2 per cent) and two (1·5 per cent) patients in the LPPG and LDG groups (P = 0·026) respectively. In multivariable analysis higher BMI was a risk factor for postoperative complications (odds ratio 1·17, 95 per cent c.i. 1·04 to 1·32; P = 0·011). Death at 90 days was zero in both groups. Conclusion: Postoperative complications and mortality was comparable in patients undergoing LPPG and LDG. Registration number: NCT02595086 (http://www.clinicaltrials.gov).-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrectomy-
dc.subject.MESHHumans-
dc.subject.MESHLaparoscopy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPylorus-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleShort-Term outcomes of a multicentre randomized clinical trial comparing laparoscopic pylorus-preserving gastrectomy with laparoscopic distal gastrectomy for gastric cancer (the KLASS-04 trial)-
dc.typeArticle-
dc.identifier.pmid34487147-
dc.contributor.affiliatedAuthorHan, SU-
dc.type.localJournal Papers-
dc.identifier.doi10.1093/bjs/znab295-
dc.citation.titleThe British journal of surgery-
dc.citation.volume108-
dc.citation.number9-
dc.citation.date2021-
dc.citation.startPage1043-
dc.citation.endPage1049-
dc.identifier.bibliographicCitationThe British journal of surgery, 108(9). : 1043-1049, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1365-2168-
dc.relation.journalidJ000071323-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse