157 368

Cited 0 times in

Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus.

Authors
Chun, SK; Sun, W; Park, JJ; Jung, MW
Citation
Neurobiology of learning and memory, 86(3):322-329, 2006
Journal Title
Neurobiology of learning and memory
ISSN
1074-74271095-9564
Abstract
The dentate gyrus (DG) is among the few areas in the mammalian brain where production of new neurons continues in the adulthood. Although its functional significance is not completely understood, several lines of evidence suggest the role of DG neurogenesis in learning and memory. Considering that long-term potentiation (LTP) is a prime candidate for the process underlying hippocampal learning and memory, these results raise the possibility that LTP and neurogenesis are closely related. Here, we investigated whether or not LTP induction in the afferent pathway triggers enhanced proliferation of progenitor cells in the DG. LTP was induced by tetanic stimulation in perforant path-DG synapses in one hemisphere, and the number of newly generated progenitor (BrdU-labeled) cells in the DG was quantified. Compared with the control hemisphere (stimulated with low-frequency pulses), the LTP-induced hemisphere contained a significantly higher number of newly generated progenitor cells in the dorsal as well as ventral DG. When CPP, an NMDA receptor antagonist, was administered, tetanic stimulation neither induced LTP nor enhanced progenitor cell proliferation, indicating that NMDA receptor activation, rather than tetanic stimulation per se, is responsible for enhanced progenitor proliferation in the control animal. Our results show that tetanic stimulation of perforant path sufficient to induce LTP increases progenitor proliferation in adult DG in an NMDA receptor-dependent manner.
MeSH terms
Adult Stem Cells/cytology*Adult Stem Cells/physiologyAnimalsCell Proliferation*Dentate Gyrus/cytologyDentate Gyrus/physiology*Electric StimulationLong-Term Potentiation/physiology*MalePerforant Pathway/cytologyPerforant Pathway/physiology*RatsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate/physiologyStatistics, NonparametricSynapses/physiology*
DOI
10.1016/j.nlm.2006.05.005
PMID
16824772
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정, 민환
Full Text Link
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse