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Plasma neurofilament light chain level and orthostatic hypotension in early Parkinson’s disease

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dc.contributor.authorPark, DG-
dc.contributor.authorKim, JW-
dc.contributor.authorAn, YS-
dc.contributor.authorChang, J-
dc.contributor.authorYoon, JH-
dc.date.accessioned2023-01-10T00:39:16Z-
dc.date.available2023-01-10T00:39:16Z-
dc.date.issued2021-
dc.identifier.issn0300-9564-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23928-
dc.description.abstractTo delineate the impact of non-motor markers (REM sleep behavior disorder (RBD), orthostatic hypotension (OH), cardiac sympathetic denervation, hyposmia) on neuronal injury in early-stage Parkinson’s disease (PD), we measured the plasma neurofilament light chain (NFL) level of PD patients and evaluated its relationship with these markers. The study population comprised a cohort of 77 patients with PD and 54 controls. OH was assessed using 5-min head-up tilt-table test. Other clinical parameters such as RBD, Unified Parkinson’s Disease Rating Scale (UPDRS), cognition, Cross‐Cultural Smell Identification Test (CCSIT), white matter hyperintensity (WMH), cardiac metaiodobenzylguanidine (MIBG) and striatal dopamine transporter (DAT) uptake were assessed. Plasma NFL levels were measured using Simoa platform. During mean 24.8 months of follow-up, 70 patients remained PD, 5 patients converted to Parkinson-plus syndrome (P + converter), and 2 were lost to follow-up. NFL level did not differ between PD and control groups (age-adjusted means 10.40 pg/mL vs 9.51 pg/mL, p = 0.151), but PD patients with OH (median 15.31 pg/mL) had higher levels compared with those without OH (median 9.2 pg/mL, p = 0.008), as well as the control group (median 9.7 pg/mL, p = 0.002). P + converter group had the highest plasma NFL level (38.17 pg/mL, p < 0.001). In a multiple regression analysis, OH, age, and disease duration independently correlated with plasma NFL level. This finding adds biomarker-based evidence for poor clinical outcomes associated with OH in patients with PD.-
dc.language.isoen-
dc.subject.MESH3-Iodobenzylguanidine-
dc.subject.MESHHumans-
dc.subject.MESHHypotension, Orthostatic-
dc.subject.MESHIntermediate Filaments-
dc.subject.MESHParkinson Disease-
dc.subject.MESHREM Sleep Behavior Disorder-
dc.titlePlasma neurofilament light chain level and orthostatic hypotension in early Parkinson’s disease-
dc.typeArticle-
dc.identifier.pmid34568970-
dc.subject.keywordMIBG-
dc.subject.keywordNFL-
dc.subject.keywordOrthostatic hypotension-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordRBD-
dc.contributor.affiliatedAuthorPark, DG-
dc.contributor.affiliatedAuthorAn, YS-
dc.contributor.affiliatedAuthorChang, J-
dc.contributor.affiliatedAuthorYoon, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00702-021-02423-y-
dc.citation.titleJournal of neural transmission (Vienna, Austria : 1996)-
dc.citation.volume128-
dc.citation.number12-
dc.citation.date2021-
dc.citation.startPage1853-
dc.citation.endPage1861-
dc.identifier.bibliographicCitationJournal of neural transmission (Vienna, Austria : 1996), 128(12). : 1853-1861, 2021-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1435-1463-
dc.relation.journalidJ003009564-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
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