Cited 0 times in Scipus Cited Count

Systemic Immune-Inflammatory Marker of High Meld Patients Is Associated With Early Mortality After Liver Transplantation

DC Field Value Language
dc.contributor.authorKim, T-
dc.contributor.authorSim, J-
dc.contributor.authorHong, SY-
dc.contributor.authorKim, BW-
dc.description.abstractThe scarcity of deceased donor livers has led to allocation of grafts to only the most seriously ill patients with a high Model for End-Stage Liver Disease (MELD) score, which has resulted in a high mortality rate after deceased donor liver transplantation (DDLT). The aim of this study is to identify risk factors for posttransplant mortality and thereby reduce futile outcomes in DDLT. Between 2013 and 2019, 57 recipients with MELD scores ≥30 underwent DDLT in our center. We retrieved data and identified the risk factors for 90-day posttransplant mortality. The perioperative clinical and laboratory parameters of patients who did or did not survive for 90 days were subjected to logistic regression analysis. Twelve patients died within 90 days. Results of univariate analysis indicated that the differences in patient survival were determined by the amount of intraoperative platelets transfused, the presence of posttransplant septicemia, and systemic immune-inflammation index (SII) at the time of listing with MELD scores ≥30. Multivariate analysis revealed that an SII ≥870 (× 109/L) and posttransplant septicemia were independent risk factors for 90-day mortality. Twenty-two patients had SIIs ≥870, and 13 of these patients had posttransplant septicemia. Of the 13 patients, 90-day mortality occurred in 10 cases. However, in 35 patients with SIIs <870, 90-day mortality due to posttransplant septicemia was recorded only in 1 patient. In conclusion, a preoperative SII ≥870 in a patient with a high MELD score may be a significant risk factor for early posttransplant mortality. Because posttransplant septicemia in patients with high SIIs can lead to fatality, a more intensive effort to prevent infection is needed for patients undergoing DDLT carrying such risk factors to avoid futile liver transplantation.-
dc.subject.MESHEnd Stage Liver Disease-
dc.subject.MESHLiver Transplantation-
dc.subject.MESHLiving Donors-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.titleSystemic Immune-Inflammatory Marker of High Meld Patients Is Associated With Early Mortality After Liver Transplantation-
dc.contributor.affiliatedAuthorKim, T-
dc.contributor.affiliatedAuthorSim, J-
dc.contributor.affiliatedAuthorHong, SY-
dc.contributor.affiliatedAuthorKim, BW-
dc.type.localJournal Papers-
dc.citation.titleTransplantation proceedings-
dc.identifier.bibliographicCitationTransplantation proceedings, 53(10). : 2945-2952, 2021-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Files in This Item:
There are no files associated with this item.


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.