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A population-based study of TyG index distribution and its relationship to cardiometabolic risk factors in children and adolescents

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dc.contributor.authorYoon, JS-
dc.contributor.authorShim, YS-
dc.contributor.authorLee, HS-
dc.contributor.authorHwang, IT-
dc.contributor.authorHwang, JS-
dc.date.accessioned2023-01-10T00:39:24Z-
dc.date.available2023-01-10T00:39:24Z-
dc.date.issued2021-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23956-
dc.description.abstractThe purpose of this study was to present age- and sex-specific distributions of the triglyceride-glucose (TyG) index and to evaluate their relationship with cardiometabolic risk factors in children and adolescents. A total of 7404 participants aged 10–18 years from the Korean National Health and Nutrition Survey were included as the reference population. The TyG index was calculated as ln(fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). The percentile of the TyG index exhibited a steady linear relationship with age for both sexes. TyG index significantly correlated with waist circumference (WC) standard deviation score (SDS; r = 0.110, p < 0.001), systolic blood pressure (SBP; r = 0.104, p < 0.001), diastolic blood pressure (DBP; r = 0.083, p < 0.001), glucose (r = 0.220, p < 0.001), high-density lipoprotein cholesterol (HDL-C; r = − 0.325, p < 0.001), and triglycerides (TG; r = 0.926, p < 0.001). Multiple linear regression analysis revealed that the TyG index was significantly associated with WC SDS (β = 0.116, p < 0.001), SBP (β = 2.009, p < 0.001), DBP (β = 1.464, p < 0.001), glucose (β = 3.376, p < 0.001), HDL-C (β = − 6.431, p < 0.001), and TG (β = 85.518, p < 0.001). Our results suggest that the TyG index has a steady linear distribution for sex and age in children and adolescents and constitutes an indicator for predicting metabolic disorders that could lead to cardiovascular disease later in life.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHBlood Glucose-
dc.subject.MESHBlood Pressure-
dc.subject.MESHCardiometabolic Risk Factors-
dc.subject.MESHChild-
dc.subject.MESHConfounding Factors, Epidemiologic-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHTriglycerides-
dc.subject.MESHWaist Circumference-
dc.titleA population-based study of TyG index distribution and its relationship to cardiometabolic risk factors in children and adolescents-
dc.typeArticle-
dc.identifier.pmid34880367-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654923/-
dc.contributor.affiliatedAuthorShim, YS-
dc.contributor.affiliatedAuthorLee, HS-
dc.contributor.affiliatedAuthorHwang, JS-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/s41598-021-03138-6-
dc.citation.titleScientific reports-
dc.citation.volume11-
dc.citation.number1-
dc.citation.date2021-
dc.citation.startPage23660-
dc.citation.endPage23660-
dc.identifier.bibliographicCitationScientific reports, 11(1). : 23660-23660, 2021-
dc.identifier.eissn2045-2322-
dc.relation.journalidJ020452322-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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