Cited 0 times in Scipus Cited Count

Clusters of Severe Eosinophilic Asthma in a Korean Asthma Cohort

DC Field Value Language
dc.contributor.authorLee, JH-
dc.contributor.authorAn, J-
dc.contributor.authorWon, HK-
dc.contributor.authorSeo, B-
dc.contributor.authorKim, JH-
dc.contributor.authorPark, SY-
dc.contributor.authorKim, MH-
dc.contributor.authorShin, YS-
dc.contributor.authorJung, JW-
dc.contributor.authorSong, WJ-
dc.contributor.authorLee, T-
dc.contributor.authorKwon, HS-
dc.contributor.authorLee, JH-
dc.contributor.authorKim, JH-
dc.contributor.authorKim, SH-
dc.contributor.authorChang, YS-
dc.contributor.authorCho, YS-
dc.contributor.authorNahm, DH-
dc.contributor.authorJang, AS-
dc.contributor.authorPark, JW-
dc.contributor.authorYoon, HJ-
dc.contributor.authorCho, SH-
dc.contributor.authorCho, YJ-
dc.contributor.authorChoi, BW-
dc.contributor.authorMoon, HB-
dc.contributor.authorKim, TB-
dc.date.accessioned2023-01-10T00:39:24Z-
dc.date.available2023-01-10T00:39:24Z-
dc.date.issued2022-
dc.identifier.issn0025-7931-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/23958-
dc.description.abstractBackground: Targeted therapies have broadened the available treatment options for patients with severe eosinophilic asthma (SEA). However, differences in the magnitude of treatment responses among patients indicate the presence of various underlying pathophysiological processes and patient subgroups. Objectives: We aimed to describe the characteristics of SEA and identify its patient subgroups. Methods: Clinical data from the Cohort for Reality and Evolution of Adult Asthma in Korea were analyzed. Cluster analysis was performed among those with SEA using 5 variables, namely, prebronchodilator forced expiratory volume in 1 s, body mass index, age at symptom onset, smoking amount, and blood eosinophil counts. Results: Patients with SEA showed prevalent sensitization to aeroallergens, decreased lung function, and poor asthma control status. Cluster analysis revealed 3 distinctive subgroups among patients with SEA. Cluster 1 (n = 177) consisted of patients reporting the lowest blood eosinophils (median, 346.8 cells/μL) and modest severe asthma with preserved lung function during the 12-month treatment period. Cluster 2 (n = 42) predominantly included smoking males with severe persistent airway obstruction and moderate eosinophilia (median, 451.8 cells/μL). Lastly, cluster 3 (n = 95) included patients with the most severe asthma, the highest eosinophil levels (median, 817.5 cells/μL), and good treatment response in terms of improved lung function and control status. Conclusions: Three subgroups were identified in SEA through the cluster analysis. The distinctive features of each cluster may help physicians predict patients who will respond to biologics with greater magnitude of clinical improvement. Further research regarding the underlying pathophysiology and clinical importance of each subgroup is warranted.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAsthma-
dc.subject.MESHEosinophils-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHLeukocyte Count-
dc.subject.MESHMale-
dc.subject.MESHPulmonary Eosinophilia-
dc.titleClusters of Severe Eosinophilic Asthma in a Korean Asthma Cohort-
dc.typeArticle-
dc.identifier.pmid34915526-
dc.subject.keywordAsthma-
dc.subject.keywordBiologics-
dc.subject.keywordCluster analysis-
dc.subject.keywordSevere eosinophilic asthma-
dc.contributor.affiliatedAuthorShin, YS-
dc.contributor.affiliatedAuthorNahm, DH-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000520492-
dc.citation.titleRespiration; international review of thoracic diseases-
dc.citation.volume101-
dc.citation.number5-
dc.citation.date2022-
dc.citation.startPage465-
dc.citation.endPage475-
dc.identifier.bibliographicCitationRespiration; international review of thoracic diseases, 101(5). : 465-475, 2022-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1423-0356-
dc.relation.journalidJ000257931-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse