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Development of two-photon fluorescence probe for detecting cyclooxygenase-2 level in human colorectal cancer tissue

Park, SJ | Cho, MK | Lee, DJ | Song, DH | Lim, CS | Noh, CK  | Lee, DM | Choi, KS  | Shin, SJ  | Kim, HM
Sensors and actuators. B, Chemical, 330. : 129329-129329, 2021
Journal Title
Sensors and actuators. B, Chemical
Cyclooxygenase-2 is overexpressed in all stages of cancers and thus serves as an attractive biomarker for early cancer diagnosis. In this study, we report a two-photon probe (SCX) for cyclooxygenase-2 which can reflect the intracellular enzyme level and distinguish between cancerous and normal tissue in colorectal cancer patients. SCX is based on a novel two-photon fluorophore (PBT) possessing phenanthrene donor and benzothiazole acceptor, and indomethacin as a COX-2 targeting unit. The in vitro and cell imaging studies revealed that SCX could distinguish the COX-2 expression levels in cancerous and normal cells. Furthermore, for the first time, normal and cancerous tissues could clearly be distinguished in human biopsy samples by using a COX-2 responsible two-photon probe.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Ajou Authors
노, 충균  |  신, 성재  |  최, 경숙
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