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Effect of omalizumab as add-on therapy to quality of life questionnaire for korean asthmatics (Kaqlq) in korean patients with severe persistent allergic asthma

Authors
Jung, JW | Park, HS  | Park, CS | Cho, SH | Choi, IS | Moon, HB | Kwon, SS | Yoon, HJ | Park, JW | Lee, JM | Choi, DC | Choi, BW
Citation
The Korean journal of internal medicine, 36(4). : 1001-1013, 2021
Journal Title
The Korean journal of internal medicine
ISSN
1226-33032005-6648
Abstract
Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma. Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement in the quality of life with the additional administration of omalizumab for 24 weeks in Korean patients with severe persistent allergic asth-ma. Results: Of the 44 patients, 31.8% were men and the mean age was 49.8 ± 11.8 years. A score improvement of 0.5 points or more in the Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) was noted in 50.0% (22/44) of the patinets. In the improved group, the baseline total immunoglobulin E (IgE) level and the amount of omalizumab used were higher, and the day and night asthma symptoms were more severe, compared to those in the non-improved group. According to the Global Evaluation of Treatment Effectiveness, favorable outcomes were found in 78.6% of patients. The Korean asthma control test (p < 0.005) and forced expira-tory volume in 1 second % predicted (FEV1%; p < 0.01) improved significantly in patients who received omalizumab treatment, compared to that at week 0, and the total dose of rescue systemic corticosteroids significantly decreased (p < 0.05). The improved group on KAQLQ showed a significant improvement in FEV1% (p < 0.001). Conclusions: Omalizumab can be considered a biological treatment for Korean patients with severe allergic asthma. It is recommended to consider omalizumab as add-on therapy in patients with high baseline total IgE levels and severe asthma symptoms.
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MeSH

DOI
10.3904/kjim.2020.549
PMID
34237826
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Ajou Authors
박, 해심
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