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Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation.
DC Field | Value | Language |
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dc.contributor.author | Jung, KH | - |
dc.contributor.author | Chu, K | - |
dc.contributor.author | Lee, ST | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Sinn, DI | - |
dc.contributor.author | Kim, SU | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Roh, JK | - |
dc.date.accessioned | 2011-04-21T02:25:33Z | - |
dc.date.available | 2011-04-21T02:25:33Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2409 | - |
dc.description.abstract | The adult brain harbors multipotent stem cells, which reside in specialized niches that support self-renewal. Granulocyte colony-stimulating factor (G-CSF) induces bone marrow stem cells proliferation and mobilization from their niche, and activates endothelial cell proliferation, which might help to establish a vascular niche for neural stem cells (NSCs). Here, we show that G-CSF induced receptor-mediated proliferation and differentiation of neural precursors in human NSCs cultures and in adult rat brain in vivo. In human NSCs cultures, G-CSF activated STAT3 and 5, and increased VEGF and its receptor, VEGFR2 (Flk-1) expression, and VEGFR2 tyrosine kinase inhibitor blocked the neurogenesis stimulated by G-CSF. G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation. | - |
dc.language.iso | en | - |
dc.subject.MESH | Brain | - |
dc.subject.MESH | Bromodeoxyuridine | - |
dc.subject.MESH | Calcium-Binding Protein, Vitamin D-Dependent | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Interactions | - |
dc.subject.MESH | Embryo, Mammalian | - |
dc.subject.MESH | Endothelial Cells | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Enzyme Inhibitors | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Granulocyte Colony-Stimulating Factor | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Indoles | - |
dc.subject.MESH | Laminin | - |
dc.subject.MESH | Neurons | - |
dc.subject.MESH | Receptors, Granulocyte Colony-Stimulating Factor | - |
dc.subject.MESH | STAT Transcription Factors | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Stem Cells | - |
dc.subject.MESH | Tubulin | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A | - |
dc.title | Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. | - |
dc.type | Article | - |
dc.identifier.pmid | 16423324 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0006-8993(05)01732-4 | - |
dc.contributor.affiliatedAuthor | 김, 승업 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.brainres.2005.12.037 | - |
dc.citation.title | Brain research | - |
dc.citation.volume | 1073-1074 | - |
dc.citation.date | 2006 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | 201 | - |
dc.identifier.bibliographicCitation | Brain research, 1073-1074. : 190-201, 2006 | - |
dc.identifier.eissn | 1872-6240 | - |
dc.relation.journalid | J000068993 | - |
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