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Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease.

Authors
Lee, ST; Park, JE; Lee, K; Kang, L; Chu, K; Kim, SU; Kim, M; Roh, JK
Citation
Journal of neuroscience methods, 152(1-2):250-254, 2006
Journal Title
Journal of neuroscience methods
ISSN
0165-02701872-678X
Abstract
A loss of neostriatal neurons is a characteristic of Huntington's disease (HD), and neural tissue transplantation has been performed directly into the striatum. Since the neural stem cells have ability to migrate into the lesion site, we administered immortalized neural stem-like cells (NSC) into the ventricle or via a tail vein following unilateral intrastriatal quinolinic acid lesioning in Sprague-Dawley rats. To identify transplanted NSC, cells were encoded with lac Z and beta-galactosidase histochemistry was performed. lac Z+ cells were detected in the lesioned striatum but tissue damage or tumor formation was not observed. This study shows that NSC migrate into the striatum, either from ventricle or from the systemic circulation, providing less invasive routes for stem cell application in HD.
MeSH terms
AnimalsCell Line, Transformed/transplantation*Cell MovementHumansHuntington Disease/chemically inducedHuntington Disease/therapy*ImmunohistochemistryImmunosuppressionInjections, IntraventricularLac Operon/geneticsMaleNeurons/transplantation*Quinolinic Acid/toxicityRatsRats, Sprague-DawleyStem Cell Transplantation/methods*Stereotaxic Techniques
DOI
10.1016/j.jneumeth.2005.09.013
PMID
16257450
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김승업
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