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Remodeling of synaptic structures in the motor cortex following spinal cord injury.

Authors
Kim, BG; Dai, HN; McAtee, M; Vicini, S; Bregman, BS
Citation
Experimental neurology, 198(2):401-415, 2006
Journal Title
Experimental neurology
ISSN
0014-48861090-2430
Abstract
After spinal cord injury (SCI), structural reorganization occurs at multiple levels of the motor system including the motor cortex, and this remodeling may underlie recovery of motor function. The present study determined whether SCI leads to a remodeling of synaptic structures in the motor cortex. Dendritic spines in the rat motor cortex were visualized by confocal microscopy in fixed slices, and their density and morphology were analyzed after an overhemisection injury at C4 level. Spine density decreased at 7 days and partially recovered by 28 days. Spine head diameter significantly increased in a layer-specific manner. SCI led to a higher proportion of longer spines especially at 28 days, resulting in a roughly 10% increase in mean spine length. In addition, filopodium-like long dendritic protrusions were more frequently observed after SCI, suggesting an increase in synaptogenic events. This spine remodeling was accompanied by increased expression of polysialylated neural cell adhesion molecule, which attenuates adhesion between the pre- and postsynaptic membranes, in the motor cortex from as early as 3 days to 2 weeks after injury, suggesting a decrease in synaptic adhesion during the remodeling process. These results demonstrate time-dependent changes in spine density and morphology in the motor cortex following SCI. This synaptic remodeling seems to proceed with a time scale ranging from days to weeks. Elongation of dendritic spines may indicate a more immature and modifiable pattern of synaptic connectivity in the motor cortex being reorganized following SCI.
MeSH terms
Amino Acids/diagnostic useAnalysis of VarianceAnimalsBlotting, Western/methodsDendritic Spines/pathologyDendritic Spines/physiologyDiagnostic ImagingDisease Models, AnimalFemaleIntracellular Signaling Peptides and Proteins/metabolismMembrane Proteins/metabolismMotor Cortex/pathology*Neural Cell Adhesion Molecule L1/metabolismNeuronal Plasticity/physiology*Pseudopodia/pathologyPseudopodia/physiologyRatsSialic Acids/metabolismSpinal Cord Injuries/pathology*Spinal Cord Injuries/physiopathology*Synapses/pathology*Synapses/physiology*Time Factors
DOI
10.1016/j.expneurol.2005.12.010
PMID
16443221
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
AJOU Authors
김, 병곤
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