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Identification of cathepsin d as a plasma biomarker for Alzheimer’s disease

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dc.contributor.authorKim, JW-
dc.contributor.authorJung, SY-
dc.contributor.authorKim, Y-
dc.contributor.authorHeo, H-
dc.contributor.authorHong, CH-
dc.contributor.authorSeo, SW-
dc.contributor.authorChoi, SH-
dc.contributor.authorSon, SJ-
dc.contributor.authorLee, S-
dc.contributor.authorChang, J-
dc.date.accessioned2023-01-26T06:10:33Z-
dc.date.available2023-01-26T06:10:33Z-
dc.date.issued2021-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24143-
dc.description.abstractAlthough Alzheimer’s disease (AD) is the most common neurodegenerative disease, there are still no drugs available to treat or prevent AD effectively. Here, we examined changes in levels of selected proteins implicated in the pathogenesis of AD using plasma samples of control subjects and patients with cognition impairment. To precisely categorize the disease, fifty‐six participants were examined with clinical cognitive tests, amyloid positron emission tomography (PET) scan, and white matter hyperintensities scored by magnetic resonance imaging. Plasma cathepsin D levels of the subjects were examined by immunoblotting and enzyme‐linked immunosorbent assay (ELISA). Correlation of plasma cathepsin D levels with AD‐related factors and clinical characteristics were examined by statistical analysis. By analyzing quantitative immunoblot and ELISA, we found that the plasma level of cathepsin D, a major lysosomal protease, was decreased in the group with amyloid plaque deposition at the brain compared to the control group. The level of plasma cathepsin D was negatively correlated with clinical dementia rating scale sum of boxes (CDR‐SB) scores. In addition, our integrated multivariable logistic regression model suggests the high performance of plasma cathepsin D level for discriminating AD from non‐AD. These results suggest that the plasma cathepsin D level could be developed as a diagnostic biomarker candidate for AD.-
dc.language.isoen-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAlzheimer Disease-
dc.subject.MESHApolipoprotein E4-
dc.subject.MESHBiomarkers-
dc.subject.MESHCathepsin D-
dc.subject.MESHEducational Status-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMental Status and Dementia Tests-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHROC Curve-
dc.titleIdentification of cathepsin d as a plasma biomarker for Alzheimer’s disease-
dc.typeArticle-
dc.identifier.pmid33445607-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827175/-
dc.subject.keywordAlzheimer’s disease-
dc.subject.keywordCathepsin D-
dc.subject.keywordCDR‐SB score-
dc.subject.keywordPlasma biomarker-
dc.contributor.affiliatedAuthorHong, CH-
dc.contributor.affiliatedAuthorSon, SJ-
dc.contributor.affiliatedAuthorChang, J-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/cells10010138-
dc.citation.titleCells-
dc.citation.volume10-
dc.citation.number1-
dc.citation.date2021-
dc.citation.startPage138-
dc.citation.endPage138-
dc.identifier.bibliographicCitationCells, 10(1). : 138-138, 2021-
dc.identifier.eissn2073-4409-
dc.relation.journalidJ020734409-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
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