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GC and MS properties of β-blockers as tert-butyldimethylsilyl derivatives and as ethoxycarbonyl/trimethylsilyl derivatives.

Authors
Paik, MJ; Nguyen, DT; Kim, KR
Citation
Chromatographia, 64(11-12):673-679, 2006
Journal Title
Chromatographia
ISSN
0009-58931612-1112
Abstract
Fourteen β-blockers in pre-dried free base forms were simultaneously converted into tert-butyldimethylsilyl (TBDMS) derivatives in one-step. As a different approach, β-blockers were directly transformed into N-ethoxycarbonyl (EOC) derivatives in aqueous solution, followed by extraction and trimethylsilyl (TMS) derivatization. The retention index sets measured by DB-5 and DB-17 dual-column GC were characteristic for each β-blocker as TBDMS- and EOC/TMS derivatives. Their characteristic fragmentation patterns obtained by GC-MS facilitated easier peak identification of each β-blocker. The overall EOC/TMS method for assays of 14 β-blockers in aqueous solution was linear with acceptable precision and accuracy. © 2006 Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH.
Keywords
Gas chromatography–mass spectrometryEthoxycarbonylation/trimethylsilylationβ-Blockerstert-Butyldimethylsilylation
Appears in Collections:
Journal Papers > Research Organization > Institute for Neuroregeneration & Stem Cell Research
AJOU Authors
백, 만정
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