Cited 0 times in Scipus Cited Count

Biomarkers for Locally Advanced Hepatocellular Carcinoma Patients Treated with Liver-Directed Combined Radiotherapy

DC Field Value Language
dc.contributor.authorChung, SY-
dc.contributor.authorKim, KJ-
dc.contributor.authorSeong, J-
dc.date.accessioned2023-02-13T06:23:21Z-
dc.date.available2023-02-13T06:23:21Z-
dc.date.issued2022-
dc.identifier.issn2235-1795-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24554-
dc.description.abstractINTRODUCTION: In the era of biomarker-driven cancer therapy, robust biomarkers for hepatocellular carcinoma (HCC) have not been well-defined. In this hypothesis-generating study, we investigated biomarkers that can be incorporated to predict treatment outcomes in patients with locally advanced HCC who are administered liver-directed combined radiotherapy (LDCRT). METHODS: Ninety-nine patients with HCC who were treated with conventional fractionation LDCRT between July 2016 and October 2018 were enrolled in this prospective single-arm study. Clinical outcomes and possible serum biomarkers, including soluble programmed cell death ligand-1 (sPD-L1), interleukin (IL)-10, IL-6, cell-free DNA (cfDNA), inter-alpha inhibitor H4, and interferon-gamma, were analyzed. The primary endpoint was disease progression, and additional endpoints were local failure-free rate, intrahepatic failure-free rate, and lung metastasis-free rate. RESULTS: The median follow-up period was 18.7 months. The 1-year progression-free rate was 38.2%. Increasing baseline sPD-L1 per pg/mL, previous treatment history, protein induced by vitamin K absence-II >1,629 mAU/mL, and multiple tumors were the adverse factors for progression based on multivariate analysis. Survival tree analysis revealed three prognostic groups for progression, in which patients with multiple lesions and baseline sPD-L1 >/=41.07 pg/mL showed the worst outcomes. For dynamic changes in biomarker levels, sPD-L1 fold change and cfDNA fold-change values were unfavorable factors for progression. CONCLUSION: Baseline sPD-L1, sPD-L1 fold change, and cfDNA fold-change values showed the highest potential as biomarkers for predicting post-treatment progression after LDCRT in HCC patients. By incorporating clinical factors, these biomarkers may be useful for devising a biomarker-driven treatment paradigm in locally advanced HCC.-
dc.language.isoen-
dc.titleBiomarkers for Locally Advanced Hepatocellular Carcinoma Patients Treated with Liver-Directed Combined Radiotherapy-
dc.typeArticle-
dc.identifier.pmid35949293-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218622-
dc.subject.keywordBiomarker-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordLiver-directed combined radiotherapy-
dc.subject.keywordRadiotherapy-
dc.subject.keywordTumor progression-
dc.contributor.affiliatedAuthorChung, SY-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000522000-
dc.citation.titleLiver cancer-
dc.citation.volume11-
dc.citation.number3-
dc.citation.date2022-
dc.citation.startPage247-
dc.citation.endPage255-
dc.identifier.bibliographicCitationLiver cancer, 11(3). : 247-255, 2022-
dc.identifier.eissn1664-5553-
dc.relation.journalidJ022351795-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Files in This Item:
35949293.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse