Cited 0 times in Scipus Cited Count

Aberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty

DC Field Value Language
dc.contributor.authorShim, YS-
dc.contributor.authorLee, HS-
dc.contributor.authorHwang, JS-
dc.date.accessioned2023-02-21T04:33:50Z-
dc.date.available2023-02-21T04:33:50Z-
dc.date.issued2022-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24725-
dc.description.abstractThe Notch signaling pathway is highly conserved during evolution. It has been well documented that Notch signaling regulates cell proliferation, migration, and death in the nervous, cardiac, and endocrine systems. The Notch pathway is relatively simple, but its activity is regulated by numerous complex mechanisms. Ligands bind to Notch receptors, inducing their activation and cleavage. Various post-translational processes regulate Notch signaling by affecting the synthesis, secretion, activation, and degradation of Notch pathway-related proteins. Through such post-translational regulatory processes, Notch signaling has versatile effects in many tissues, including the hypothalamus. Recently, several studies have reported that mutations in genes related to the Notch signaling pathway were found in patients with central precocious puberty (CPP). CPP is characterized by the early activation of the hypothalamus-pituitary-gonadal (HPG) axis. Although genetic factors play an important role in CPP development, few associated genetic variants have been identified. Aberrant Notch signaling may be associated with abnormal pubertal development. In this review, we discuss the current knowledge about the role of the Notch signaling pathway in puberty and consider the potential mechanisms underlying CPP.-
dc.language.isoen-
dc.subject.MESHHumans-
dc.subject.MESHMutation-
dc.subject.MESHPuberty-
dc.subject.MESHPuberty, Precocious-
dc.subject.MESHReceptors, Notch-
dc.subject.MESHSignal Transduction-
dc.titleAberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty-
dc.typeArticle-
dc.identifier.pmid35328752-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8950842-
dc.subject.keywordCentral precocious puberty-
dc.subject.keywordEtiology-
dc.subject.keywordNotch signaling pathway-
dc.subject.keywordPuberty-
dc.contributor.affiliatedAuthorShim, YS-
dc.contributor.affiliatedAuthorLee, HS-
dc.contributor.affiliatedAuthorHwang, JS-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/ijms23063332-
dc.citation.titleInternational journal of molecular sciences-
dc.citation.volume23-
dc.citation.number6-
dc.citation.date2022-
dc.citation.startPage3332-
dc.citation.endPage3332-
dc.identifier.bibliographicCitationInternational journal of molecular sciences, 23(6). : 3332-3332, 2022-
dc.identifier.eissn1422-0067-
dc.relation.journalidJ014220067-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Files in This Item:
35328752.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse