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Risk Prediction Model Based on Magnetic Resonance Elastography-Assessed Liver Stiffness for Predicting Posthepatectomy Liver Failure in Patients with Hepatocellular Carcinoma

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dc.contributor.authorCho, HJ-
dc.contributor.authorAhn, YH-
dc.contributor.authorSim, MS-
dc.contributor.authorEun, JW-
dc.contributor.authorKim, SS-
dc.contributor.authorKim, BW-
dc.contributor.authorHuh, J-
dc.contributor.authorLee, JH-
dc.contributor.authorKim, JK-
dc.contributor.authorLee, B-
dc.contributor.authorCheong, JY-
dc.contributor.authorKim, B-
dc.date.accessioned2023-02-21T04:34:08Z-
dc.date.available2023-02-21T04:34:08Z-
dc.date.issued2022-
dc.identifier.issn1976-2283-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24801-
dc.description.abstractBACKGROUND/AIMS: Posthepatectomy liver failure (PHLF) is a major complication that increases mortality in patients with hepatocellular carcinoma after surgical resection. The aim of this retrospective study was to evaluate the utility of magnetic resonance elastography-assessed liver stiffness (MRE-LS) for the prediction of PHLF and to develop an MRE-LS-based risk prediction model. METHODS: A total of 160 hepatocellular carcinoma patients who underwent surgical resection with available preoperative MRE-LS data were enrolled. Clinical and laboratory parameters were collected from medical records. Logistic regression analyses were conducted to identify the risk factors for PHLF and develop a risk prediction model. RESULTS: PHLF was present in 24 patients (15%). In the multivariate logistic analysis, high MRE-LS (kPa; odds ratio [OR] 1.49, 95% confidence interval [CI] 1.12 to 1.98, p=0.006), low serum albumin (-0.55; OR 3.72, 95% CI 1.15 to 12.04, p=0.028), and higher serum alpha-fetoprotein (>100 ng/mL; OR 3.53, 95% CI 1.20 to 10.40, p=0.022) were identified as independent risk factors for PHLF. A risk prediction model for PHLF was established using the multivariate logistic regression equation. The area under the receiver operating characteristic curve (AUC) of the risk prediction model was 0.877 for predicting PHLF and 0.923 for predicting grade B and C PHLF. In leave-one-out cross-validation, the risk model showed good performance, with AUCs of 0.807 for all-grade PHLF and 0. 871 for grade B and C PHLF. CONCLUSIONS: Our novel MRE-LS-based risk model had excellent performance in predicting PHLF, especially grade B and C PHLF.-
dc.language.isoen-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHElasticity Imaging Techniques-
dc.subject.MESHHepatectomy-
dc.subject.MESHHumans-
dc.subject.MESHLiver Failure-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHRetrospective Studies-
dc.titleRisk Prediction Model Based on Magnetic Resonance Elastography-Assessed Liver Stiffness for Predicting Posthepatectomy Liver Failure in Patients with Hepatocellular Carcinoma-
dc.typeArticle-
dc.identifier.pmid34810297-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924801-
dc.subject.keywordCarcinoma-
dc.subject.keywordhepatocellular-
dc.subject.keywordHepatectomy-
dc.subject.keywordMagnetic resonance elastography-
dc.subject.keywordHepatic fibrosis-
dc.subject.keywordLiver failure-
dc.contributor.affiliatedAuthorCho, HJ-
dc.contributor.affiliatedAuthorEun, JW-
dc.contributor.affiliatedAuthorKim, SS-
dc.contributor.affiliatedAuthorKim, BW-
dc.contributor.affiliatedAuthorHuh, J-
dc.contributor.affiliatedAuthorLee, JH-
dc.contributor.affiliatedAuthorKim, JK-
dc.contributor.affiliatedAuthorCheong, JY-
dc.type.localJournal Papers-
dc.identifier.doi10.5009/gnl210130-
dc.citation.titleGut and liver-
dc.citation.volume16-
dc.citation.number2-
dc.citation.date2022-
dc.citation.startPage277-
dc.citation.endPage289-
dc.identifier.bibliographicCitationGut and liver, 16(2). : 277-289, 2022-
dc.identifier.eissn2005-1212-
dc.relation.journalidJ019762283-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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