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Molecular and radiopathologic spectrum between HCC and intrahepatic cholangiocarcinoma

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dc.contributor.authorJeon, Y-
dc.contributor.authorKwon, SM-
dc.contributor.authorRhee, H-
dc.contributor.authorYoo, JE-
dc.contributor.authorChung, T-
dc.contributor.authorWoo, HG-
dc.contributor.authorPark, YN-
dc.date.accessioned2023-02-27T07:12:39Z-
dc.date.available2023-02-27T07:12:39Z-
dc.date.issued2023-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24830-
dc.description.abstractBACKGROUND AND AIMS: Primary liver cancers (LCs), including HCC and intrahepatic cholangiocarcinoma (iCCA), are derived from a common developmental lineage, conferring a molecular spectrum between them. To elucidate the molecular spectrum, we performed an integrative analysis of transcriptome profiles associated with patients' radiopathologic features. APPROACH AND RESULTS: We identified four LC subtypes (LC1-LC4) from RNA-sequencing profiles, revealing intermediate subtypes between HCC and iCCA. LC1 is a typical HCC characterized by active bile acid metabolism, telomerase reverse transcriptase promoter mutations, and high uptake of gadoxetic acid in MRI. LC2 is an iCCA-like HCC characterized by expression of the progenitor cell-like trait, tumor protein p53 mutations, and rim arterial-phase hyperenhancement in MRI. LC3 is an HCC-like iCCA, mainly small duct (SD) type, associated with HCC-related etiologic factors. LC4 is further subclassified into LC4-SD and LC4-large duct iCCAs according to the pathological features, which exhibited distinct genetic variations (e.g., KRAS , isocitrate dehydrogenase 1/2 mutation, and FGF receptor 2 fusion), stromal type, and prognostic outcomes. CONCLUSIONS: Our integrated view of the molecular spectrum of LCs can identify subtypes associated with transcriptomic, genomic, and radiopathologic features, providing mechanistic insights into heterogeneous LC progression.-
dc.language.isoen-
dc.subject.MESHBile Duct Neoplasms-
dc.subject.MESHBile Ducts, Intrahepatic-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHCholangiocarcinoma-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.titleMolecular and radiopathologic spectrum between HCC and intrahepatic cholangiocarcinoma-
dc.typeArticle-
dc.identifier.pmid35124821-
dc.contributor.affiliatedAuthorWoo, HG-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/hep.32397-
dc.citation.titleHepatology (Baltimore, Md.)-
dc.citation.volume77-
dc.citation.number1-
dc.citation.date2023-
dc.citation.startPage92-
dc.citation.endPage108-
dc.identifier.bibliographicCitationHepatology (Baltimore, Md.), 77(1). : 92-108, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1527-3350-
dc.relation.journalidJ002709139-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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