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Lung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects

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dc.contributor.authorWoo, HY-
dc.contributor.authorRhee, H-
dc.contributor.authorYoo, JE-
dc.contributor.authorKim, SH-
dc.contributor.authorChoi, GH-
dc.contributor.authorKim, DY-
dc.contributor.authorWoo, HG-
dc.contributor.authorLee, HS-
dc.contributor.authorPark, YN-
dc.date.accessioned2023-02-27T07:12:50Z-
dc.date.available2023-02-27T07:12:50Z-
dc.date.issued2022-
dc.identifier.issn1478-3223-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24879-
dc.description.abstractBACKGROUND & AIMS: Extrahepatic metastasis from hepatocellular carcinoma (HCC) is a catastrophic event, yet organ-specific pathological characteristics of metastatic HCC remain unclear. We aimed to characterize the pathological aspects of HCC metastases to various organs. METHODS: We collected intrahepatic HCC (cohort 1, n = 322) and extrahepatic metastatic HCC (cohort 2, n = 130) samples. Clinicopathological evaluation and immunostaining for K19, CD34, alphaSMA, fibroblast-associated protein (FAP), CAIX, VEGF, PD-L1, CD3, CD8, Foxp3, CD163 and epithelial-mesenchymal transition (EMT)-related markers were performed. RESULTS: Independent factors for extrahepatic metastasis included BCLC stage B-C, microvascular invasion (MVI), vessels encapsulating tumour clusters (VETC)-HCC, K19 and FAP expression, and CD163+ macrophage infiltration (cohort 1, P < .05 for all). Lung metastases (n = 63) had the highest proportion of VETC-HCC and macrotrabecular-massive (MTM)-HCC. Lymph node metastases (n = 19) showed significantly high rates of EMT-high features, K19 expression, fibrous tumour stroma with alphaSMA and FAP expression, high immune cell infiltration, PD-L1 expression (combined positive score), CD3+, CD8+, Foxp3+ T cell and CD163+ macrophage infiltration (adjusted P < .05 for all). In both cohorts, EMT-high HCCs showed higher rates of K19 expression, fibrous tumour stroma, high immune cell infiltration, PD-L1 expression and CD3+ T cell infiltration, whereas EMT-low HCCs were more frequent among VETC-HCCs (P < .05 for all). Overall phenotypic features were not significantly different between paired primary-metastatic HCCs (n = 32). CONCLUSIONS: Metastatic HCCs to various organs showed different pathological features. VETC and MTM subtypes were related to lung metastasis, whereas K19 expression, EMT-high features with fibrous tumour stroma and high immune cell infiltration were related to lymph node metastasis.-
dc.language.isoen-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHEpithelial-Mesenchymal Transition-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHLung-
dc.subject.MESHLymphatic Metastasis-
dc.titleLung and lymph node metastases from hepatocellular carcinoma: Comparison of pathological aspects-
dc.typeArticle-
dc.identifier.pmid34490997-
dc.subject.keywordepithelial-mesenchymal transition-
dc.subject.keywordextrahepatic metastasis-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordkeratin 19-
dc.subject.keywordmacrotrabecular-massive-
dc.subject.keywordvessels encapsulating tumour clusters-
dc.contributor.affiliatedAuthorWoo, HG-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/liv.15051-
dc.citation.titleLiver international-
dc.citation.volume42-
dc.citation.number1-
dc.citation.date2022-
dc.citation.startPage199-
dc.citation.endPage209-
dc.identifier.bibliographicCitationLiver international, 42(1). : 199-209, 2022-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1478-3231-
dc.relation.journalidJ014783223-
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Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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