Cited 0 times in Scipus Cited Count

Three Clinical Clusters Identified through Hierarchical Cluster Analysis Using Initial Laboratory Findings in Korean Patients with Systemic Lupus Erythematosus

DC Field Value Language
dc.contributor.authorJung, JY-
dc.contributor.authorLee, HY-
dc.contributor.authorLee, E-
dc.contributor.authorKim, HA-
dc.contributor.authorYoon, D-
dc.contributor.authorSuh, CH-
dc.date.accessioned2023-02-27T07:12:59Z-
dc.date.available2023-02-27T07:12:59Z-
dc.date.issued2022-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24921-
dc.description.abstractSystemic lupus erythematosus (SLE) is a heterogeneous disorder with diverse clinical manifestations. This study classified patients by combining laboratory values at SLE diagnosis via hierarchical cluster analysis. Linear discriminant analysis was performed to construct a model for predicting clusters. Cluster analysis using data from 389 patients with SLE yielded three clusters with different laboratory characteristics. Cluster 1 had the youngest age at diagnosis and showed significantly lower lymphocyte and platelet counts and hemoglobin and complement levels and the highest erythrocyte sedimentation rate (ESR) and anti-double-stranded DNA (dsDNA) antibody level. Cluster 2 showed higher white blood cell (WBC), lymphocyte, and platelet counts and lower ESR and anti-dsDNA antibody level. Cluster 3 showed the highest anti-nuclear antibody titer and lower WBC and lymphocyte counts. Within approximately 171 months, Cluster 1 showed higher SLE Disease Activity Index scores and number of cumulative manifestations, including malar rash, alopecia, arthritis, and renal disease, than did Clusters 2 and 3. However, the damage index and mortality rate did not differ significantly between them. In conclusion, the cluster analysis using the initial laboratory findings of the patients with SLE identified three clusters. While disease activities, organ involvements, and management patterns differed between the clusters, damages and mortalities did not.-
dc.language.isoen-
dc.titleThree Clinical Clusters Identified through Hierarchical Cluster Analysis Using Initial Laboratory Findings in Korean Patients with Systemic Lupus Erythematosus-
dc.typeArticle-
dc.identifier.pmid35566532-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105234-
dc.subject.keywordclassification-
dc.subject.keywordcluster analysis-
dc.subject.keywordlaboratory-
dc.subject.keywordlinear discriminant analysis-
dc.subject.keywordsystemic lupus erythematosus-
dc.contributor.affiliatedAuthorJung, JY-
dc.contributor.affiliatedAuthorKim, HA-
dc.contributor.affiliatedAuthorSuh, CH-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/jcm11092406-
dc.citation.titleJournal of clinical medicine-
dc.citation.volume11-
dc.citation.number9-
dc.citation.date2022-
dc.citation.startPage2406-
dc.citation.endPage2406-
dc.identifier.bibliographicCitationJournal of clinical medicine, 11(9). : 2406-2406, 2022-
dc.identifier.eissn2077-0383-
dc.relation.journalidJ020770383-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Files in This Item:
35566532.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse