Cited 0 times in Scipus Cited Count

Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus

DC Field Value Language
dc.contributor.authorPark, N-
dc.contributor.authorJeon, JY-
dc.contributor.authorJeong, E-
dc.contributor.authorKim, S-
dc.contributor.authorYoon, D-
dc.date.accessioned2023-02-27T07:13:03Z-
dc.date.available2023-02-27T07:13:03Z-
dc.date.issued2022-
dc.identifier.issn2093-596X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/24938-
dc.description.abstractBACKGROUND: Most studies of systematic drug repositioning have used drug-oriented data such as chemical structures, gene expression patterns, and adverse effect profiles. As it is often difficult to prove repositioning candidates' effectiveness in real-world clinical settings, we used patient-centered real-world data for screening repositioning candidate drugs for multiple diseases simultaneously, especially for diabetic complications. METHODS: Using the National Health Insurance Service-National Sample Cohort (2002 to 2013), we analyzed claims data of 43,048 patients with type 2 diabetes mellitus (age >/=40 years). To find repositioning candidate disease-drug pairs, a nested case-control study was used for 29 pairs of diabetic complications and the drugs that met our criteria. To validate this study design, we conducted an external validation for a selected candidate pair using electronic health records. RESULTS: We found 24 repositioning candidate disease-drug pairs. In the external validation study for the candidate pair cerebral infarction and glycopyrrolate, we found that glycopyrrolate was associated with decreased risk of cerebral infarction (hazard ratio, 0.10; 95% confidence interval, 0.02 to 0.44). CONCLUSION: To reduce risks of diabetic complications, it would be possible to consider these candidate drugs instead of other drugs, given the same indications. Moreover, this methodology could be applied to diseases other than diabetes to discover their repositioning candidates, thereby offering a new approach to drug repositioning.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHComorbidity-
dc.subject.MESHDiabetes Complications-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHDrug Repositioning-
dc.subject.MESHHumans-
dc.titleDrug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus-
dc.typeArticle-
dc.identifier.pmid35144331-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901955-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordDrug repositioning-
dc.subject.keywordRetrospective studies-
dc.subject.keywordType 2-
dc.contributor.affiliatedAuthorJeon, JY-
dc.type.localJournal Papers-
dc.identifier.doi10.3803/ENM.2021.1275-
dc.citation.titleEndocrinology and metabolism (Seoul, Korea)-
dc.citation.volume37-
dc.citation.number1-
dc.citation.date2022-
dc.citation.startPage65-
dc.citation.endPage73-
dc.identifier.bibliographicCitationEndocrinology and metabolism (Seoul, Korea), 37(1). : 65-73, 2022-
dc.identifier.eissn2093-5978-
dc.relation.journalidJ02093596X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Files in This Item:
35144331.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse