157 222

Cited 47 times in

Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra.

Authors
Jeong, HK; Jou, I; Joe, EH
Citation
Experimental & molecular medicine, 42(12):823-832, 2010
Journal Title
Experimental & molecular medicine
ISSN
1226-36132092-6413
Abstract
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.
MeSH terms
AnimalsAstrocytes/pathologyCell DeathEncephalitis/chemically inducedEncephalitis/immunologyEncephalitis/pathology*Injections, IntravenousLipopolysaccharides/pharmacology*MaleMicroglia/pathologyNeutrophil InfiltrationRatsRats, Sprague-DawleySubstantia Nigra/immunologySubstantia Nigra/pathology*
DOI
10.3858/emm.2010.42.12.085
PMID
20962566
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
주일로조은혜
Full Text Link
Files in This Item:
emm-42-823-832.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse