121 332

Cited 31 times in

Current trends in the epidemiological and pathological characteristics of gastrointestinal stromal tumors in Korea, 2003-2004.

Authors
Cho, MY; Sohn, JH; Kim, JM; Kim, KM; Park, YS; Kim, WH; Jung, JS; Jung, ES; Jin, SY; Kang, DY; Park, JB; Park, HS; Choi, YD; Sung, SH; Kim, YB; Kim, H; Bae, YK; Kang, M; Chang, HJ; Chae, YS; Lee, HE; Park, do Y; Lee, YS; Kang, YK; Kim, HK; Chang, HK; Hong, SW; Choi, YH; Shin, O; Gu, M; Kim, YW; Kim, GI; Chang, SJ
Citation
Journal of Korean medical science, 25(6):853-862, 2010
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1%) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.
MeSH terms
AdolescentAdultAge FactorsAgedAged, 80 and overAntigens, CD34/metabolismFemaleGastrointestinal Stromal Tumors/diagnosisGastrointestinal Stromal Tumors/epidemiologyGastrointestinal Stromal Tumors/pathology*HumansMaleMiddle AgedMitosisNeoplasm InvasivenessPrognosisRepublic of Korea/epidemiologyRisk FactorsS100 Proteins/metabolismSex FactorsSurvival Analysis
DOI
10.3346/jkms.2010.25.6.853
PMID
20514305
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김영배
Full Text Link
Files in This Item:
jkms-25-853-862.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse