Cited 0 times in Scipus Cited Count

Safety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study

DC Field Value Language
dc.contributor.authorBang, JB-
dc.contributor.authorOh, CK-
dc.contributor.authorKim, YS-
dc.contributor.authorKim, SH-
dc.contributor.authorYu, HC-
dc.contributor.authorKim, CD-
dc.contributor.authorJu, MK-
dc.contributor.authorSo, BJ-
dc.contributor.authorLee, SH-
dc.contributor.authorHan, SY-
dc.contributor.authorJung, CW-
dc.contributor.authorKim, JK-
dc.contributor.authorAhn, HJ-
dc.contributor.authorLee, SH-
dc.contributor.authorJeon, JY-
dc.description.abstractINTRODUCTION: This prospective multicenter study aimed at investigating the safety and metabolic advantages of steroid withdrawal (SW) therapy in kidney transplant recipients with tacrolimus-mycophenolate mofetil-based immunosuppression. METHODS: We analyzed 179 recipients who received kidney transplantation from March 2016 and September 2018. In 179 recipients, 114 patients maintained an immunosuppressive regimen including steroids (steroid continuation [SC] group). The remaining 65 patients were determined to withdraw steroid therapy after 6 months posttransplant (SW group). Metabolic parameters and graft functions of the two groups were evaluated. RESULTS: The estimated glomerular filtration rates at 12 months posttransplant were 67.29 +/- 20.29 ml/min/1.73 m(2) in SC group and 73.72 +/- 17.57 ml/min/1.73 m(2) in SW group (p < .001). The acute rejection occurred to four recipients in the SC group (3.5%) and no acute rejection occurred to SW group recipients during the 6-2 months posttransplant period. Oral glucose tolerance tests revealed that recipients in the SW group were more improved in glucose metabolism than the SC group during 6-12 months posttransplant. In addition, cholesterol levels and blood pressure decreased after the withdrawal of steroids in the SW group. CONCLUSION: In conclusion, a 6-month withdrawal of steroids in recipients with low immunological risk and stable graft function can be safely conducted and result in improvement of metabolic profiles. Stable recipients without biopsy-proven acute rejection and proteinuria can safely withdraw from steroids out of a maintenance immunosuppressive regimen 6-months posttransplant. A long-term follow-up study is needed to verify our results.-
dc.subject.MESHGraft Rejection-
dc.subject.MESHKidney Transplantation-
dc.subject.MESHMycophenolic Acid-
dc.subject.MESHProspective Studies-
dc.titleSafety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study-
dc.subject.keywordglucose tolerance test-
dc.subject.keywordkidney transplantation-
dc.contributor.affiliatedAuthorBang, JB-
dc.contributor.affiliatedAuthorOh, CK-
dc.contributor.affiliatedAuthorLee, SH-
dc.contributor.affiliatedAuthorJeon, JY-
dc.type.localJournal Papers-
dc.citation.titleImmunity, inflammation and disease-
dc.identifier.bibliographicCitationImmunity, inflammation and disease, 10(3). : e576-e576, 2022-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Files in This Item:


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.