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SHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy

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dc.contributor.authorPandey, S-
dc.contributor.authorLee, MC-
dc.contributor.authorLim, JW-
dc.contributor.authorChoung, YH-
dc.contributor.authorJang, KJ-
dc.contributor.authorPark, SB-
dc.contributor.authorKim, JE-
dc.contributor.authorChung, JH-
dc.contributor.authorGarg, P-
dc.date.accessioned2023-03-24T06:26:53Z-
dc.date.available2023-03-24T06:26:53Z-
dc.date.issued2022-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25082-
dc.description.abstractThe near-perivascular accumulation in solid tumors and short-lived span in circulation, derails even the most competent nanoparticles (NPs) from achieving their maximum therapeutic potential. Moreover, delivering them across the blood brain/tumor barrier (BBB/BTB) is further challenging to sought anticancer effect. To address these key challenges, we designed a linearly aligned nucleic acid-complexed polydixylitol-based polymeric nanochains (X-NCs), with inherent hyperosmotic properties enabling transmigration of the BBB/BTB and navigation through deeper regions of the brain tumor. The high aspect ratio adds shape-dependent functional aspects to parent particles by providing effective payload increment and nuclear factor of activated T cells-5 (NFAT5)-mediated cellular uptake. Therefore, serine hydroxymethyltransferase 1 (SHMT1) siRNA-loaded nanochains not only demonstrated to transmigrate the BTB, but also resulted in remarkably reducing the tumor size to 97% in the glioblastoma xenograft brain tumor mouse models. Our study illustrates how the hyperosmotic nanochains with high aspect ratio and aligned structure can accelerate a therapeutic effect in aggressive brain tumors post-transmigration of the BBB/BTB by utilizing an NFAT5 mode of uptake mechanism.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBlood-Brain Barrier-
dc.subject.MESHBrain Neoplasms-
dc.subject.MESHGlioblastoma-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHNanoparticles-
dc.subject.MESHRNA, Small Interfering-
dc.titleSHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy-
dc.typeArticle-
dc.identifier.pmid34998172-
dc.subject.keywordAspect ratio-
dc.subject.keywordBBB/BTB-
dc.subject.keywordHyperosmotic-
dc.subject.keywordNanochain-
dc.subject.keywordNFAT5-
dc.subject.keywordSHMT1-
dc.subject.keywordTransmigration-
dc.contributor.affiliatedAuthorChoung, YH-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.biomaterials.2021.121359-
dc.citation.titleBiomaterials-
dc.citation.volume281-
dc.citation.date2022-
dc.citation.startPage121359-
dc.citation.endPage121359-
dc.identifier.bibliographicCitationBiomaterials, 281. : 121359-121359, 2022-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1878-5905-
dc.relation.journalidJ001429612-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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