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Safety and efficacy of clonazepam in patients with hemifacial spasm: A double-blind, randomized, placebo-controlled trial

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dc.contributor.authorBaek, SH-
dc.contributor.authorShin, JY-
dc.contributor.authorSohn, SY-
dc.contributor.authorPark, KH-
dc.contributor.authorKim, JS-
dc.contributor.authorKim, B-
dc.contributor.authorAhn, SH-
dc.contributor.authorChoi, K-
dc.contributor.authorHong, YH-
dc.contributor.authorSung, JJ-
dc.date.accessioned2023-03-24T06:26:59Z-
dc.date.available2023-03-24T06:26:59Z-
dc.date.issued2022-
dc.identifier.issn1353-8020-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25109-
dc.description.abstractINTRODUCTION: Hemifacial spasm (HFS) is an involuntary intermittent twitching of the facial muscles. Medical and surgical treatments can be considered for HFS. Among medical treatments, clonazepam is a benzodiazepine used to treat epilepsy, psychiatric symptoms, and movement disorders. This study aimed to investigate the efficacy and safety of clonazepam for the treatment of HFS. METHODS: This randomized double-blind placebo-controlled trial prospectively enrolled patients with HFS aged 20-79 years. The patients were randomly assigned in a 1:1 ratio to receive either clonazepam (0.5 mg twice daily) or a placebo for 4 weeks. All participants underwent clinical assessment and laboratory tests at baseline and visit 2. The primary endpoint was the clinical global impression-improvement (CGI-I) score at visit 2. RESULTS: A total of 34 patients with HFS assessed for eligibility were enrolled between April 2015 and November 2016. Among them, two patients were withdrawn before randomization. Thus, the intention-to-treat analysis included 32 patients with HFS. The median CGI-I scores at visit 2 did not differ significantly between the clonazepam (3; range 1-6) and placebo (3.5; range 3-5) groups. In the safety analysis, only mild or no serious adverse events were observed. CONCLUSION: The results of this study demonstrated the safety of clonazepam in patients with HFS. However, clonazepam did not show a statistically significant effect on HFS. Further studies are needed to provide evidence of the clinical benefits in patients with HFS.-
dc.language.isoen-
dc.subject.MESHClonazepam-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHHemifacial Spasm-
dc.subject.MESHHumans-
dc.subject.MESHTreatment Outcome-
dc.titleSafety and efficacy of clonazepam in patients with hemifacial spasm: A double-blind, randomized, placebo-controlled trial-
dc.typeArticle-
dc.identifier.pmid35987013-
dc.subject.keywordClonazepam-
dc.subject.keywordEfficacy-
dc.subject.keywordHemifacial spasm-
dc.subject.keywordSafety-
dc.contributor.affiliatedAuthorSohn, SY-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.parkreldis.2022.07.025-
dc.citation.titleParkinsonism & related disorders-
dc.citation.volume103-
dc.citation.date2022-
dc.citation.startPage1-
dc.citation.endPage6-
dc.identifier.bibliographicCitationParkinsonism & related disorders, 103. : 1-6, 2022-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-5126-
dc.relation.journalidJ013538020-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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