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Down-regulated surfactant protein B in obese asthmatics

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dc.contributor.authorCao, TBT-
dc.contributor.authorMoon, JY-
dc.contributor.authorYoo, HJ-
dc.contributor.authorBan, GY-
dc.contributor.authorKim, SH-
dc.contributor.authorPark, HS-
dc.date.accessioned2023-03-24T06:27:04Z-
dc.date.available2023-03-24T06:27:04Z-
dc.date.issued2022-
dc.identifier.issn0954-7894-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25127-
dc.description.abstractBACKGROUND: Obesity is a common comorbid condition in adult asthmatics and known as a feature of asthma severity. However, the molecular mechanism under obesity-induced inflammation has not yet been fully understood. OBJECTIVE: Considering the essential role of hydrophobic surfactant protein B (SP-B) in lung function, SP-B was targeted to examine its involvement in the development of obesity-induced airway inflammation in asthmatics. METHODS: The aim was to examine an alteration in circulating SP-B according to obesity in adult asthmatics, 129 asthmatics were enrolled and classified into 3 groups (obese, overweight and normal-weight groups) according to body mass index (BMI). Circulating SP-B levels were determined by enzyme-linked immunosorbent assay. Four single nucleotide polymorphisms of SFTPB gene were genotyped. Serum ceramide levels were measured by liquid chromatography-tandem mass spectrometry. RESULTS: Significantly lower serum SP-B levels were noted in the obese group than in the overweight or normal-weight group (p = .002). The serum SP-B level was significantly correlated with serum levels of C18:0 ceramide and transforming growth factor beta 1 as well as BMI (r = -0.200; r = -0.215; r = -0.332, p < .050 for all). An inverse correlation was noted between serum SP-B and fractional exhaled nitric oxide levels in female asthmatics (r = -0.287, p = .009). Genetic predisposition of the SFTPB gene at 9306 A>G to the obese and overweight groups was noted. CONCLUSION: Obesity altered ceramide metabolism leading to pulmonary surfactant dysfunction and impaired resolution of airway inflammation, finally contributing to the phenotypes of obese asthmatics.-
dc.language.isoen-
dc.subject.MESHAsthma-
dc.subject.MESHCeramides-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHObesity-
dc.subject.MESHOverweight-
dc.subject.MESHSurface-Active Agents-
dc.subject.MESHTransforming Growth Factor beta-
dc.titleDown-regulated surfactant protein B in obese asthmatics-
dc.typeArticle-
dc.identifier.pmid35294785-
dc.subject.keywordasthma-
dc.subject.keywordceramide-
dc.subject.keywordobesity-
dc.subject.keywordsurfactant protein B, airway, inflammation-
dc.contributor.affiliatedAuthorKim, SH-
dc.contributor.affiliatedAuthorPark, HS-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/cea.14124-
dc.citation.titleClinical and experimental allergy-
dc.citation.volume52-
dc.citation.number11-
dc.citation.date2022-
dc.citation.startPage1321-
dc.citation.endPage1329-
dc.identifier.bibliographicCitationClinical and experimental allergy, 52(11). : 1321-1329, 2022-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1365-2222-
dc.relation.journalidJ009547894-
Appears in Collections:
Journal Papers > Hospital > Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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