Cited 0 times in Scipus Cited Count

Clinical Features and Drug Retention of TNF Inhibitors in Older Patients with Ankylosing Spondylitis: Results from the KOBIO Registry

Kim, JW  | Lee, EA | Kim, HA  | Suh, CH  | Jung, JY
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 36(3). : 411-419, 2022
Journal Title
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
OBJECTIVES: This study aimed to analyse the clinical features and outcomes of and reasons for discontinuing tumour necrosis factor (TNF) inhibitor therapy in older patients with ankylosing spondylitis (AS). METHODS: Data were extracted from the nationwide Korean College of Rheumatology Biologics registry. Clinical variables and outcomes were compared, and drug retention rate was evaluated. RESULTS: Among 1524 patients with AS treated with TNF inhibitors, 306 were aged >/= 50 years ('older patients'). Fewer patients were male, the incidence of hypertension and diabetes was higher (all p < 0.001), and the proportion of peripheral arthritis (35.6 vs. 27.1%), Ankylosing Spondylitis Disease Activity Score‒erythrocyte sedimentation rate (4.0 +/- 1.1 vs. 3.6 +/- 1.0), and Bath Ankylosing Spondylitis Functional Index (4.2 +/- 2.6 vs. 3.3 +/- 2.5) were all higher in older patients. Although the drug retention rate was lower (log-rank p = 0.018) and lack of efficacy and adverse events were more frequent in older patients (both p < 0.001), drug retention rates were not different after propensity score matching (log-rank p = 0.23). Improvements in disease activity and manifestations were comparable between groups, except for the incidence of peripheral arthritis, which decreased significantly less in older patients over 3 and 5 years. CONCLUSION: Improvements in disease-related clinical factors and drug retention rates were not different between older and younger patients with AS receiving TNF inhibitors. However, the incidence of adverse events was higher in older patients.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Ajou Authors
김, 지원  |  김, 현아  |  서, 창희  |  정, 주양
Files in This Item:
There are no files associated with this item.


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.