IFN-lambda endocytosis and IFN-lambda responsive promoter activation are dependent on cholesterol.
Cho, O; Hong, SH; Kim, JS; Yoon, JK; Kim, K; Chwae, YJ; Shin, HJ; Park, S
Cytokine, 51(1):93-100, 2010
Recently, a relationship between receptor endocytosis and downstream signaling has been documented for several immunomodulatory molecules. However, endocytosis of interferon-lambdas (IFN-lambdas) and its impact on IFN-lambda function has not been studied. We show that IFN-lambda is internalized through a cholesterol-dependent, dynamin-independent, and Rho family of GTPase-independent pathway in HepG2 cells. Furthermore, we demonstrate that inhibition of IFN-lambda endocytosis by cholesterol depletion suppresses the activation of IFN-lambda responsive promoters. These results suggest that IFN-lambda endocytosis participates in regulating antiviral gene induction and thus may affect antiviral immunity.
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