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IFN-lambda endocytosis and IFN-lambda responsive promoter activation are dependent on cholesterol.

Authors
Cho, O; Hong, SH; Kim, JS; Yoon, JK; Kim, K; Chwae, YJ; Shin, HJ; Park, S
Citation
Cytokine, 51(1):93-100, 2010
Journal Title
Cytokine
ISSN
1043-46661096-0023
Abstract
Recently, a relationship between receptor endocytosis and downstream signaling has been documented for several immunomodulatory molecules. However, endocytosis of interferon-lambdas (IFN-lambdas) and its impact on IFN-lambda function has not been studied. We show that IFN-lambda is internalized through a cholesterol-dependent, dynamin-independent, and Rho family of GTPase-independent pathway in HepG2 cells. Furthermore, we demonstrate that inhibition of IFN-lambda endocytosis by cholesterol depletion suppresses the activation of IFN-lambda responsive promoters. These results suggest that IFN-lambda endocytosis participates in regulating antiviral gene induction and thus may affect antiviral immunity.
MeSH terms
Cholesterol/metabolism*Dynamins/metabolismEndocytosis*/drug effectsEnzyme Inhibitors/pharmacologyGene Knockdown TechniquesHep G2 CellsHumansInterferon Regulatory Factor-1/metabolismInterferons/metabolism*KineticsPromoter Regions, Genetic/genetics*Transcriptional Activation*/drug effectsrho GTP-Binding Proteins/antagonists & inhibitors
DOI
10.1016/j.cyto.2010.03.004
PMID
20385504
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
AJOU Authors
윤준기김경민최용준신호준박선
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