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Clinical and Immunological Characterization of Perilla Seed Allergy in Children

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dc.contributor.authorJeong, K-
dc.contributor.authorLee, SY-
dc.contributor.authorJeon, SA-
dc.contributor.authorGantulga, P-
dc.contributor.authorNam, JY-
dc.contributor.authorHong, SJ-
dc.contributor.authorLee, S-
dc.date.accessioned2023-05-23T04:04:13Z-
dc.date.available2023-05-23T04:04:13Z-
dc.date.issued2023-
dc.identifier.issn1018-9068-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25516-
dc.description.abstractBackground: Perilla seeds are known to cause immediate allergic reactions. However, reports on perilla seed allergy are limited to a few case reports worldwide, and there is currently no diagnostic test for this allergy. Objective: Our objective was to analyze the clinical and immunological characteristics of perilla seed allergy and to identify allergens for the development of diagnostic methods. Methods: Twenty-one children with clinical perilla seed allergy were enrolled from 2 tertiary hospitals between September 2016 and June 2019. Using perilla seed extract, we developed a skin prick test (SPT) and an IgE enzyme-linked immunosorbent assay (ELISA) for diagnosis of perilla seed allergy. IgE immunoblotting was performed to identify putative allergenic components, and amino acid composition analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: The median age of children with perilla seed allergy was 3 years; the proportion of children with anaphylaxis was 28.6%. SPT was performed with perilla seed in 15 of 21 children, all of whom tested positive. On ELISA, 85.7% of children tested positive for perilla seed-specific IgE. Proteins with molecular weights of 50, 31-35, and 14-16 kDa bound to the sera of >50% of children with perilla seed allergy. LC-MS/MS analysis of these 3 protein fractions showed 8 putative proteins, including perilla oleosin (Accession No. 9963891), to be allergens. Conclusion: This study documented the clinical characteristics and immunological profiles of 21 children with perilla seed allergy. Our results suggest that oleosin is one of the major allergens in perilla seeds.-
dc.language.isoen-
dc.subject.MESHAllergens-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHChromatography, Liquid-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFood Hypersensitivity-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E-
dc.subject.MESHSeeds-
dc.subject.MESHSkin Tests-
dc.subject.MESHTandem Mass Spectrometry-
dc.titleClinical and Immunological Characterization of Perilla Seed Allergy in Children-
dc.typeArticle-
dc.identifier.pmid34643183-
dc.identifier.urlhttp://www.jiaci.org/summary/vol33-issue1-num2632-
dc.subject.keywordAllergen-
dc.subject.keywordAmino acids-
dc.subject.keywordAnaphylaxis-
dc.subject.keywordELISA-
dc.subject.keywordHypersensitivity-
dc.subject.keywordPerilla-
dc.subject.keywordSeeds-
dc.subject.keywordSkin test-
dc.contributor.affiliatedAuthorJeong, K-
dc.contributor.affiliatedAuthorLee, S-
dc.type.localJournal Papers-
dc.identifier.doi10.18176/jiaci.0756-
dc.citation.titleJournal of investigational allergology & clinical immunology-
dc.citation.volume33-
dc.citation.number1-
dc.citation.date2023-
dc.citation.startPage14-
dc.citation.endPage20-
dc.identifier.bibliographicCitationJournal of investigational allergology & clinical immunology, 33(1). : 14-20, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.relation.journalidJ010189068-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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