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Safety and effectiveness of aflibercept in combination with FOLFIRI in Korean patients with metastatic colorectal cancer who received oxaliplatin-containing regimen

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dc.contributor.authorBeom, SH-
dc.contributor.authorKim, JG-
dc.contributor.authorBaik, SH-
dc.contributor.authorShin, SH-
dc.contributor.authorPark, I-
dc.contributor.authorPark, YS-
dc.contributor.authorLee, MA-
dc.contributor.authorLee, S-
dc.contributor.authorJeon, SY-
dc.contributor.authorHan, SW-
dc.contributor.authorKang, MH-
dc.contributor.authorOh, J-
dc.contributor.authorKim, JS-
dc.contributor.authorKim, JY-
dc.contributor.authorAhn, MS-
dc.contributor.authorZang, DY-
dc.contributor.authorBae, BN-
dc.contributor.authorJo, HJ-
dc.contributor.authorKim, HK-
dc.contributor.authorKim, JH-
dc.contributor.authorYoon, JA-
dc.contributor.authorKim, DH-
dc.date.accessioned2023-05-23T04:04:13Z-
dc.date.available2023-05-23T04:04:13Z-
dc.date.issued2023-
dc.identifier.issn0171-5216-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25517-
dc.description.abstractPurpose: To evaluate the safety and effectiveness of aflibercept in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) in Korean patients with metastatic colorectal cancer (mCRC) who progressed with oxaliplatin-containing regimen. Methods: This was a prospective observational study conducted at 22 sites across Korea between February 2018 and September 2019. Patients aged > 19 years with a diagnosis of mCRC who were prescribed aflibercept plus FOLFIRI, after progression with an oxaliplatin-containing regimen were included. Disease assessment was performed every 6 weeks. Results: A total of 185 patients were included (males, 58.9%; right-sided tumors, 23.8%; and ECOG performance factor ≥ 1, 68.6%). A total of 514 adverse events (AEs) occurred in 134 patients, of which 206 (49.2%; 95% CI 42.0%, 56.4%) events were considered as adverse drug reactions (ADRs), 172 unexpected AEs (49.7%; 95% CI 42.5%, 56.9%), and 53 serious AEs (22.2%; 95% CI16.2%, 28.2%). The most common serious ADR was pneumonia (n = 2, 1.6%). The most common all grade hematological AE and non-hematological AE were neutropenia (21.6%) and nausea (16.2%), respectively. Over a median follow-up of 5.6 months, a total of five grade 5 (1.0%) AEs were reported. Median OS was 9.4 months, and median progression-free survival (PFS) was 7.3 months. The overall response rate was 14.6%. Right-sided tumor location and prior bevacizumab treatment were independent factors of poor PFS in multivariate analysis. Conclusion: Aflibercept in combination with FOLFIRI was effective and showed an acceptable safety profile in Korean patients with mCRC in daily clinical practice.-
dc.language.isoen-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHBevacizumab-
dc.subject.MESHCamptothecin-
dc.subject.MESHColonic Neoplasms-
dc.subject.MESHColorectal Neoplasms-
dc.subject.MESHFluorouracil-
dc.subject.MESHHumans-
dc.subject.MESHLeucovorin-
dc.subject.MESHMale-
dc.subject.MESHOxaliplatin-
dc.subject.MESHRectal Neoplasms-
dc.subject.MESHRepublic of Korea-
dc.titleSafety and effectiveness of aflibercept in combination with FOLFIRI in Korean patients with metastatic colorectal cancer who received oxaliplatin-containing regimen-
dc.typeArticle-
dc.identifier.pmid35344080-
dc.subject.keywordAcquired resistance-
dc.subject.keywordAnti-VEGF agents-
dc.subject.keywordChemotherapy-
dc.subject.keywordColorectal cancer-
dc.contributor.affiliatedAuthorAhn, MS-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00432-022-03946-x-
dc.citation.titleJournal of cancer research and clinical oncology-
dc.citation.volume149-
dc.citation.number3-
dc.citation.date2023-
dc.citation.startPage1131-
dc.citation.endPage1143-
dc.identifier.bibliographicCitationJournal of cancer research and clinical oncology, 149(3). : 1131-1143, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1432-1335-
dc.relation.journalidJ001715216-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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