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Proper regulation of β-adrenergic signal requires Btg2 gene for lipolysis and thermogenesis in response to starvation or cold acclimation in female mice

DC Field Value Language
dc.contributor.authorHong, AE-
dc.contributor.authorRyu, MS-
dc.contributor.authorLim, IK-
dc.date.accessioned2023-05-23T04:04:15Z-
dc.date.available2023-05-23T04:04:15Z-
dc.date.issued2023-
dc.identifier.issn0955-2863-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25523-
dc.description.abstractMammals maintain constant body temperature in cold environment by activating thermogenesis via adrenergic/protein kinase A (PKA) signaling. B-cell translocation gene 2 (BTG2/Tis21), induced by PKA signaling, regulates glucose and lipid metabolism in liver, yet its role in lipolysis and in thermogenesis is not explored. Here, Btg2-knockout (KO) mice failed to maintain body temperature under starvation, or in cold acclimation. And norepinephrine-induced thermogenic response was turned off earlier in the KO mice. Gender specifically, gonadal white adipose tissues (gWAT) of female-KO were very active in lipolysis in fed state, however, the fat degradation was diminished upon fasting or cold acclimation. Also, insulin sensitivity was increased in female-KO, but not in male-KO mice, along with the low bone mineral density and small brown adipose tissues (BAT). In the mechanistic aspect, expressions of UCP1 and lipases (LPL, ATGL, HSL) in gWAT of female-KO mice were significantly reduced in response to adrenergic signals. Here, we present some data that Btg2 gene is essential for properly respond to β-adrenergic signals, and plays as a negative regulator of insulin signaling in female mice.-
dc.language.isoen-
dc.subject.MESHAcclimatization-
dc.subject.MESHAdipose Tissue, Brown-
dc.subject.MESHAdrenergic Agents-
dc.subject.MESHAnimals-
dc.subject.MESHCold Temperature-
dc.subject.MESHFemale-
dc.subject.MESHLipolysis-
dc.subject.MESHMale-
dc.subject.MESHMammals-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHThermogenesis-
dc.subject.MESHUncoupling Protein 1-
dc.titleProper regulation of β-adrenergic signal requires Btg2 gene for lipolysis and thermogenesis in response to starvation or cold acclimation in female mice-
dc.typeArticle-
dc.identifier.pmid36179768-
dc.subject.keywordBtg2/TIS21-
dc.subject.keywordCold exposure-
dc.subject.keywordgWAT-
dc.subject.keywordLipolysis-
dc.subject.keywordStarvation-
dc.subject.keywordThermogenesis-
dc.contributor.affiliatedAuthorRyu, MS-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jnutbio.2022.109160-
dc.citation.titleThe Journal of nutritional biochemistry-
dc.citation.volume111-
dc.citation.date2023-
dc.citation.startPage109160-
dc.citation.endPage109160-
dc.identifier.bibliographicCitationThe Journal of nutritional biochemistry, 111. : 109160-109160, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-4847-
dc.relation.journalidJ009552863-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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