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Single-center real-world treatment outcomes of ablative fractional laser-assisted photodynamic therapy for actinic keratosis

DC Field Value Language
dc.contributor.authorKim, DC-
dc.contributor.authorHan, HJ-
dc.contributor.authorKim, SI-
dc.contributor.authorPark, B-
dc.contributor.authorKim, YC-
dc.date.accessioned2023-05-23T04:04:18Z-
dc.date.available2023-05-23T04:04:18Z-
dc.date.issued2023-
dc.identifier.issn0905-4383-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25536-
dc.description.abstractBackground: Among various treatment modalities of actinic keratosis (AK), ablative fractional laser-assisted photodynamic therapy (fractional PDT) has shown higher efficacy despite shorter incubation time. However, there are lack of real-world studies on the therapeutic response of ablative PDT for AK and the factors that can predict the therapeutic response. Purpose: The aim of this study was to analyze the association between clinical characteristics and treatment outcomes of fractional PDT. Methods: One hundred fifty-six patients who were histologically diagnosed with AK and treated with fractional PDT were retrospectively reviewed. The Kruskal–Wallis test was used to compare treatment session differences according to grades. Results: In multivariate analysis, the grade 2 category tended to be more clinically nonresponders than the grade 1 (OR, 5.17; 95% CI, 1.011–26.439; p =.048) and the group treated four or more times with ablative fractional laser-assisted PDT were more likely to show no response compared with the single treatment session group (OR, 8.78; 95% CI, 1.355–56.874; p =.023). Treatment sessions were significantly lower in grade 1 (1.72 ± 0.63, mean ± SD) when compared to grades 2 and 3, respectively (2.17 ± 0.76; 2.60 ± 1.60, mean ± SD). Recurrence was highest in grade 2, and most of them occurred after 1 year. Conclusion: On average, two treatment sessions are sufficient for AK lesions, but the thicker the lesion, the more treatment sessions may be required. Although there are relatively smaller number of grade 3 patients were included, recurrence was more frequent in higher grade of AK category, which needs special attention to thicker lesions.-
dc.language.isoen-
dc.subject.MESHAminolevulinic Acid-
dc.subject.MESHHumans-
dc.subject.MESHKeratosis, Actinic-
dc.subject.MESHLasers-
dc.subject.MESHPhotochemotherapy-
dc.subject.MESHPhotosensitizing Agents-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleSingle-center real-world treatment outcomes of ablative fractional laser-assisted photodynamic therapy for actinic keratosis-
dc.typeArticle-
dc.identifier.pmid36579473-
dc.subject.keywordactinic keratosis-
dc.subject.keywordfractional laser-
dc.subject.keywordphotodynamic therapy-
dc.subject.keywordtreatment outcome-
dc.contributor.affiliatedAuthorPark, B-
dc.contributor.affiliatedAuthorKim, YC-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/phpp.12858-
dc.citation.titlePhotodermatology, photoimmunology & photomedicine-
dc.citation.volume39-
dc.citation.number2-
dc.citation.date2023-
dc.citation.startPage116-
dc.citation.endPage121-
dc.identifier.bibliographicCitationPhotodermatology, photoimmunology & photomedicine, 39(2). : 116-121, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1600-0781-
dc.relation.journalidJ009054383-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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