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Atypical teratoid/rhabdoid tumors of the central nervous system: imaging and clinical findings in 16 children.

DC Field Value Language
dc.contributor.authorLee, IH-
dc.contributor.authorYoo, SY-
dc.contributor.authorKim, JH-
dc.contributor.authorEo, H-
dc.contributor.authorKim, OH-
dc.contributor.authorKim, IO-
dc.contributor.authorCheon, JE-
dc.contributor.authorJung, AY-
dc.contributor.authorYoon, BJ-
dc.date.accessioned2010-11-23T02:13:01Z-
dc.date.available2010-11-23T02:13:01Z-
dc.date.issued2009-
dc.identifier.issn0009-9260-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/255-
dc.description.abstractAIM: To investigate the imaging and clinical findings of central nervous system (CNS) atypical teratoid/rhabdoid tumours (AT/RTs) in children.



MATERIALS AND METHODS: The computed tomography (CT) and magnetic resonance imaging (MRI) findings and clinical records of 16 children with CNS AT/RTs were retrospectively reviewed. Tumour location, size, composition, enhancement pattern, peritumoural oedema, signal intensity (SI) on MRI and CT attenuation were evaluated.



RESULTS: A total of 17 lesions from 16 patients (median age 2.3 years, age range 0.7-15 years) were included in the evaluation. Tumour location was infratentorial for 11 lesions and supratentorial for six lesions. The mean diameter of the largest dimension for a tumour was 4 cm. The tumour was mainly solid in 65% of cases, and solid and cystic or cystic and solid in 35% of cases. The solid component of the tumours had a homogeneous iso SI (n=15) on T2-weighted MRI images and iso SI (n=14) on T1-weighted images. Moderate to strong enhancement of the solid component was noted in most cases. In spite of a large tumour size, peritumoural oedema was minimal or mild except in four cases. Rapid growth of the tumour was demonstrated in three cases. Seven patients died from tumour progression, with a mean survival time of 8.4 months (range 2-12 months).



CONCLUSION: Although the AT/RTs had non-specific imaging findings, the tumours tended to be large in size, have iso SI on T1 and T2-weighted MR images with prominent enhancement, and relatively mild peritumoural oedema. Rapid growth of the tumour was seen during the follow-up period.
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dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHBrain Neoplasms/diagnosis*-
dc.subject.MESHBrain Neoplasms/pathology-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Interpretation, Computer-Assisted/methods-
dc.subject.MESHInfant-
dc.subject.MESHKorea-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMale-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRhabdoid Tumor/diagnosis*-
dc.subject.MESHRhabdoid Tumor/pathology-
dc.subject.MESHTomography, X-Ray Computed/methods-
dc.titleAtypical teratoid/rhabdoid tumors of the central nervous system: imaging and clinical findings in 16 children.-
dc.typeArticle-
dc.identifier.pmid19185655-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0009-9260(08)00392-9-
dc.contributor.affiliatedAuthor김, 옥화-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.crad.2008.09.007-
dc.citation.titleClinical radiology-
dc.citation.volume64-
dc.citation.number3-
dc.citation.date2009-
dc.citation.startPage256-
dc.citation.endPage264-
dc.identifier.bibliographicCitationClinical radiology, 64(3):256-264, 2009-
dc.identifier.eissn1365-229X-
dc.identifier.eissn1365-229X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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