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Mapping plant interactomes using literature curated and predicted protein-protein interaction data sets.

Authors
Lee, K; Thorneycroft, D; Achuthan, P; Hermjakob, T
Citation
The Plant cell, 22(4):997-1005, 2010
Journal Title
The Plant cell
ISSN
1040-46511532-298X
Abstract
Most cellular processes are enabled by cohorts of interacting proteins that form dynamic networks within the plant proteome. The study of these networks can provide insight into protein function and provide new avenues for research. This article informs the plant science community of the currently available sources of protein interaction data and discusses how they can be useful to researchers. Using our recently curated IntAct Arabidopsis thaliana protein-protein interaction data set as an example, we discuss potentials and limitations of the plant interactomes generated to date. In addition, we present our efforts to add value to the interaction data by using them to seed a proteome-wide map of predicted protein subcellular locations.
MeSH terms
Arabidopsis/metabolismArabidopsis Proteins/*metabolismComputational Biology*Databases, Protein*Protein Interaction MappingProteome/metabolism
DOI
10.1105/tpc.109.072736
PMID
20371643
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Informatics
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